| Title: | Detection of Ketones by a Novel Technology: Dipolar Proton Transfer Reaction Mass Spectrometry (DP-PTR-MS) |
| Author(s): | Pan Y; Zhang Q; Zhou W; Zou X; Wang H; Huang C; Shen C; Chu Y; |
| Address: | "Center of Medical Physics and Technology, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. University of Science and Technology of China, Hefei, Anhui, China. Anhui Province Key Laboratory of Medical Physics and Technology, Hefei, Anhui, China. Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei, Anhui, China. Center of Medical Physics and Technology, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. chyshen@aiofm.ac.cn. Anhui Province Key Laboratory of Medical Physics and Technology, Hefei, Anhui, China. chyshen@aiofm.ac.cn" |
| DOI: | 10.1007/s13361-017-1638-7 |
| ISSN/ISBN: | 1879-1123 (Electronic) 1044-0305 (Linking) |
| Abstract: | "Proton transfer reaction mass spectrometry (PTR-MS) has played an important role in the field of real-time monitoring of trace volatile organic compounds (VOCs) due to its advantages such as low limit of detection (LOD) and fast time response. Recently, a new technology of proton extraction reaction mass spectrometry (PER-MS) with negative ions OH(-) as the reagent ions has also been presented, which can be applied to the detection of VOCs and even inorganic compounds. In this work, we combined the functions of PTR-MS and PER-MS in one instrument, thereby developing a novel technology called dipolar proton transfer reaction mass spectrometry (DP-PTR-MS). The selection of PTR-MS mode and PER-MS mode was achieved in DP-PTR-MS using only water vapor in the ion source and switching the polarity. In this experiment, ketones (denoted by M) were selected as analytes. The ketone (molecular weight denoted by m) was ionized as protonated ketone [M + H](+) [mass-to-charge ratio (m/z) m + 1] in PTR-MS mode and deprotonated ketone [M - H](-) (m/z m - 1) in PER-MS mode. By comparing the m/z value of the product ions in the two modes, the molecular weight of the ketone can be positively identified as m. Results showed that whether it is a single ketone sample or a mixed sample of eight kinds of ketones, the molecular weights can be detected with DP-PTR-MS. The newly developed DP-PTR-MS not only maintains the original advantages of PTR-MS and PER-MS in sensitive and rapid detection of ketones, but also can estimate molecular weight of ketones. Graphical Abstract »aΓ" |
| Keywords: | Dp-ptr-ms Ketone PER-MS mode PTR-MS mode VOCs; |
| Notes: | "PubMed-not-MEDLINEPan, Yue Zhang, Qiangling Zhou, Wenzhao Zou, Xue Wang, Hongmei Huang, Chaoqun Shen, Chengyin Chu, Yannan eng 2017/03/21 J Am Soc Mass Spectrom. 2017 May; 28(5):873-879. doi: 10.1007/s13361-017-1638-7. Epub 2017 Mar 17" |
