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Peptides


Title:Comparative topical pheromonotropic activity of insect pyrokinin/PBAN amphiphilic analogs incorporating different fatty and/or cholic acid components
Author(s):Nachman RJ; Teal PE; Ujvary I;
Address:"Southern Plains Agricultural Research Center, USDA, ARS, College Station, TX 77845, USA. nachman@acs.tamu.edu"
Journal Title:Peptides
Year:2001
Volume:22
Issue:2
Page Number:279 - 285
DOI: 10.1016/s0196-9781(00)00380-6
ISSN/ISBN:0196-9781 (Print) 0196-9781 (Linking)
Abstract:"This study presents a comparison of the topical pheromonotropic activity in the tobacco budworm moth of a series of amphiphilic pseudopeptide analogs of the insect pyrokinin/PBAN peptide class incorporating fatty acids of varying chain lengths. While the C16 analog fails to penetrate the moth cuticle, and the C12 only moderately so, shorter chain analogs transmigrate the moth cuticle readily with decreasing cuticle-retention properties. A cholic acid analog topically induces twice the maximal pheromone titer of injected native hormone. From a pest management perspective, these non-aromatic hydrophobic components are expected to be more environmentally benign than benzenoid components previously used in topical insect peptide analogs"
Keywords:Animals Cholic Acid Fatty Acids Moths/*physiology Neuropeptides/*chemistry/*physiology Structure-Activity Relationship;
Notes:"MedlineNachman, R J Teal, P E Ujvary, I eng Comparative Study Research Support, U.S. Gov't, Non-P.H.S. 2001/02/17 Peptides. 2001 Feb; 22(2):279-85. doi: 10.1016/s0196-9781(00)00380-6"

 
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