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Am J Obstet Gynecol

Title:		Increased breath markers of oxidative stress in normal pregnancy and in preeclampsia
Author(s):		Moretti M; Phillips M; Abouzeid A; Cataneo RN; Greenberg J;
Address:		"Menssana Research, Inc, Fort Lee, New Jersey 07024, USA"
Journal Title:		Am J Obstet Gynecol
Year:		2004
Volume:		190
Issue:		5
Page Number:		1184 - 1190
DOI:		10.1016/j.ajog.2003.11.008
ISSN/ISBN:		0002-9378 (Print) 0002-9378 (Linking)
Abstract:		"OBJECTIVES: The purpose of this study was to compare the intensity of oxidative stress in normal pregnancy, preeclampsia, and nonpregnant women using a breath test. STUDY DESIGN: We studied primiparous women in third trimester pregnancy (38 uncomplicated, 26 with preeclampsia) and 60 nonpregnant control subjects. Volatile organic compounds (VOCs) in alveolar breath were analyzed by gas chromatography/mass spectroscopy to construct the breath methylated alkane contour (BMAC), a 3-dimensional display of abundance of C4-C20 alkanes and monomethylated alkanes. RESULTS: The mean volume under curve (VUC) of the BMAC was significantly higher in preeclampsia patients than in normal pregnant women (P < .003) and nonpregnant control subjects (P < .005). A predictive model employing 5 VOCs distinguished preeclampsia from uncomplicated pregnancy (sensitivity = 92.3%, specificity = 89.7%; cross-validated sensitivity = 88.5%, specificity = 79.3%). CONCLUSION: A breath test significantly demonstrated greater oxidative stress in women with preeclampsia than in uncomplicated pregnancy and nonpregnant control subjects. The breath test accurately identified women with established preeclampsia, but further studies are required to determine if this test can predict the onset of disease"
Keywords:		Adult Alkanes/*analysis Area Under Curve Biomarkers/analysis Breath Tests/methods Case-Control Studies Female Gas Chromatography-Mass Spectrometry Gestational Age Humans Maternal Age Oxidative Stress/*physiology Pre-Eclampsia/*diagnosis Predictive Value o;
Notes:		"MedlineMoretti, Michael Phillips, Michael Abouzeid, Ahmed Cataneo, Renee N Greenberg, Joel eng Comparative Study Research Support, Non-U.S. Gov't 2004/05/29 Am J Obstet Gynecol. 2004 May; 190(5):1184-90. doi: 10.1016/j.ajog.2003.11.008"