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Nature

Title:		A brain serine/threonine protein kinase activated by Cdc42 and Rac1
Author(s):		Manser E; Leung T; Salihuddin H; Zhao ZS; Lim L;
Address:		"Institute of Molecular & Cell Biology, National University of Singapore, Kent Ridge"
Journal Title:		Nature
Year:		1994
Volume:		367
Issue:		6458
Page Number:		40 - 46
DOI:		10.1038/367040a0
ISSN/ISBN:		0028-0836 (Print) 0028-0836 (Linking)
Abstract:		"A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways"
Keywords:		Amino Acid Sequence Animals Brain/*enzymology Cattle Enzyme Activation GTP Phosphohydrolases/antagonists & inhibitors GTP-Binding Proteins/*metabolism Guanosine Diphosphate/metabolism Guanosine Triphosphate/metabolism Intracellular Signaling Peptides and;
Notes:		"MedlineManser, E Leung, T Salihuddin, H Zhao, Z S Lim, L eng Research Support, Non-U.S. Gov't England 1994/01/06 Nature. 1994 Jan 6; 367(6458):40-6. doi: 10.1038/367040a0"