| Title: | Elements of the yeast pheromone response pathway required for filamentous growth of diploids |
| Author(s): | Liu H; Styles CA; Fink GR; |
| Address: | "Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142" |
| ISSN/ISBN: | 0036-8075 (Print) 0036-8075 (Linking) |
| Abstract: | "Transmission of an external signal from receptors to downstream targets is often mediated by a conserved set of protein kinases that act in sequence (a kinase cascade). In haploid strains of Saccharomyces cerevisiae, a signal initiated by peptide pheromones is transmitted through this kinase cascade to a transcription factor STE12, which is required for the expression of many mating-specific genes. Here it was shown that in diploids some of the same kinases and STE12 are required for filamentous growth, but the pheromone receptors and guanosine triphosphate-binding protein are not required for filament formation. Thus, a similar kinase cascade is activated by different signals in haploids and diploids and mediates different developmental outcomes in the two cell types" |
| Keywords: | "Fungal Proteins/*metabolism GTP-Binding Proteins/metabolism Genes, Fungal Mating Factor Mutation Peptides/*metabolism/pharmacology Phenotype Protein Kinases/*metabolism Receptors, Mating Factor Receptors, Peptide/metabolism Saccharomyces cerevisiae/geneti;" |
| Notes: | "MedlineLiu, H Styles, C A Fink, G R eng GM 35010/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1993/12/10 Science. 1993 Dec 10; 262(5140):1741-4. doi: 10.1126/science.8259520" |
