| Title: | Feminization and alteration of Drosophila taste neurons induce reciprocal effects on male avoidance behavior |
| Author(s): | Lacaille F; Everaerts C; Ferveur JF; |
| Address: | "Unite Mixte de Recherche 5548 Associee au Centre National de la Recherche Scientifique, Faculte des Sciences, Universite de Bourgogne, 6, Bd Gabriel, 21 000, Dijon, France" |
| DOI: | 10.1007/s10519-009-9286-8 |
| ISSN/ISBN: | 1573-3297 (Electronic) 0001-8244 (Linking) |
| Abstract: | "Taste perception allows most animals to find edible food, potential mates, and avoid ingesting toxic molecules. Intriguingly, a small group of Drosophila taste neurones (expressing Gr66a-Gal4) involved in the perception of bitter substances is also used to detect 7-tricosene (7-T), a male cuticular pheromone. Male flies tend to be inhibited by 7-T whereas females are stimulated by this pheromone. To better understand their role on male courtship, Gr66a-Gal4 neurons were genetically feminized or altered with various transgenes, and the response of transgenic males was measured toward live targets carrying various amounts of 7-T, or of bitter molecules (caffeine, quinine and berberine). Surprisingly, tester males with feminized taste neurons showed an increased dose-dependent avoidance toward targets with high level of any of these substances, compared to other tester males. Conversely, males with altered neurons showed no, or very little avoidance. Moreover, the surgical ablation of the sensory appendages carrying these taste neurons differently affected the behavioral response of the various tester males. The fact that this manipulation did not affect the courtship toward control females nor the locomotor activity of tester males suggests that Gr66a-Gal4 neurons are involved in the sex-specific perception of molecules inducing male avoidance behavior" |
| Keywords: | "Alkenes/pharmacology Animals *Behavior, Animal Drosophila melanogaster/*genetics/*physiology Female Genotype Male Models, Biological Models, Genetic Neurons/*metabolism Pheromones/metabolism Sex Factors *Sexual Behavior, Animal Taste Perception/*genetics;" |
| Notes: | "MedlineLacaille, Fabien Everaerts, Claude Ferveur, Jean-Francois eng Research Support, Non-U.S. Gov't 2009/07/21 Behav Genet. 2009 Sep; 39(5):554-63. doi: 10.1007/s10519-009-9286-8. Epub 2009 Jul 19" |
