« Previous AbstractContinuous flow pulsed power plasma reactor for the treatment of aqueous solution containing volatile organic compounds and real pharmaceutical wastewater    Next AbstractAltered pheromone biosynthesis is associated with sex-specific changes in life span and behavior in Drosophila melanogaster »

Gene

Title:		Evidence for kinship between diverse G-protein coupled receptors
Author(s):		Josefsson LG;
Address:		"Department of Plant Biology, Swedish University of Agricultural Sciences, Box 7080, SE-750 07, Uppsala, Sweden. lars-goran.josefsson@vbiol.slu.se"
Journal Title:		Gene
Year:		1999
Volume:		239
Issue:		2
Page Number:		333 - 340
DOI:		10.1016/s0378-1119(99)00392-3
ISSN/ISBN:		0378-1119 (Print) 0378-1119 (Linking)
Abstract:		"In an earlier publication we described similarities at the primary sequence level between the first probable plant G-protein coupled receptor (GPCR) and three GPCR families (families A, B and F according to Kolakowski's classification) that were previously considered evolutionarily unrelated. Here we analyze further the relatedness among different GPCR families. By using PSI-BLAST, which is a search algorithm that is more potent in detecting weak similarities, one finds additional similarities between GPCR families that have not previously been described. Based on these comparisons, it is possible to divide all the GPCR families into one large clade and two smaller ones. The large clade includes the rhodopsin family (family A), the glucagon receptor family (family B), cyclic AMP receptors (family F), an Arabidopsis thaliana receptor, the Frizzled family and probably also the STE3 pheromone receptors (family E) and vomeronasal receptors type 1. The smaller clades consist of, in one case, BOSS and the GABA-B family of receptors (family C), and in the other the STE2 pheromone receptors (family D) alone. Although our findings are likely to reflect a common ancestry within each of these clades, whether or not two or all three of the clades also share an even more ancient ancestor between them remains an open question that cannot be answered from our present data"
Keywords:		"Amino Acid Sequence Animals Arabidopsis/genetics *Drosophila Proteins Drosophila melanogaster/genetics Eye Proteins/genetics GTP-Binding Proteins/*metabolism Membrane Glycoproteins/genetics Molecular Sequence Data Phylogeny Receptors, Cell Surface/*geneti;"
Notes:		"MedlineJosefsson, L G eng Research Support, Non-U.S. Gov't Netherlands 1999/11/05 Gene. 1999 Nov 1; 239(2):333-40. doi: 10.1016/s0378-1119(99)00392-3"