| Title: | Chemical composition of smoke produced by open versus laparoscopic surgery for cholecystectomy |
| Author(s): | Hsu FL; Ho TW; Chang C; Wu JM; Lin MT; |
| Address: | "Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taiwan. Program in Liberal Medical Education (PLME) and the Department of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, USA. Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taiwan; Department of Surgery, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu County 300, Taiwan. Electronic address: wujm0531@ntu.edu.tw" |
| DOI: | 10.1016/j.hpb.2022.02.002 |
| ISSN/ISBN: | 1477-2574 (Electronic) 1365-182X (Linking) |
| Abstract: | "BACKGROUND: Smoke produced by traditional open surgery (TOS) has long been considered hazardous to medical staff. Compared with TOS, minimally invasive surgery under carbon dioxide pneumoperitoneum is associated with a faster recovery and less wound pain. However, the impact of oxygen-deficient environment on the chemical contents of smoke has not been comprehensively assessed. METHODS: This research evaluated the chemical composition and volatile organic compound (TVOC) level in smoke produced by open cholecystectomy (OC) versus laparoscopic cholecystectomy (LC) for gallbladder diseases. Smoke samples were collected and analyzed via gas chromatography-mass spectrometry. Chemical compounds were further grouped according to molecular weight and toxicity. RESULTS: Compared with the OC, LC had significantly higher halocarbon and TVOC levels but lower cycloalkene and aldehyde levels. No halocarbons were isolated from OC specimens. When stratified based on molecular weight, LC had a bimodal pattern (i.e., high levels of small-sized [<60 Da] and large-sized [>120 Da] compounds). There was no difference in terms of toxicity types, incidence, and severity associated with detected compounds between two groups. CONCLUSION: LC is associated with a higher TVOC level and proportion of low- and high-molecular-weight organic compounds. Further strategies of evacuating these health hazards and preventing smoke leakage through trocars should be considered" |
| Keywords: | "Cholecystectomy *Cholecystectomy, Laparoscopic/adverse effects *Gallbladder Diseases/surgery Humans *Laparoscopy Smoke/adverse effects/analysis;" |
| Notes: | "MedlineHsu, Francis Li-Tien Ho, Te-Wei Chang, Christopher Wu, Jin-Ming Lin, Ming-Tsan eng Research Support, Non-U.S. Gov't England 2022/02/28 HPB (Oxford). 2022 Aug; 24(8):1335-1340. doi: 10.1016/j.hpb.2022.02.002. Epub 2022 Feb 10" |
