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Dermatitis

Title:		Isothiazolinone in Residential Interior Wall Paint: A High-Performance Liquid Chromatographic-Mass Spectrometry Analysis
Author(s):		Goodier MC; Siegel PD; Zang LY; Warshaw EM;
Address:		"Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health/Health Effects Laboratory Division, Morgantown, WV"
Journal Title:		Dermatitis
Year:		2018
Volume:		29
Issue:		6
Page Number:		332 - 338
DOI:		10.1097/DER.0000000000000410
ISSN/ISBN:		2162-5220 (Electronic) 1710-3568 (Print) 1710-3568 (Linking)
Abstract:		"BACKGROUND: There is limited information regarding isothiazolinone content in residential wall paints in the United States. OBJECTIVE: The aim of this study was to evaluate the prevalence of 5 isothiazolinones-methylisothiazolinone (MI), methylchloroisothiazolinone, benzisothiazolinone (BIT), butyl BIT, and octylisothiazolinone-in US residential wall paints. METHODS: Forty-seven paints were obtained from retailers in Minneapolis/St Paul, Minnesota. Paint samples were assessed for the presence of the 5 isothiazolinones using high-performance liquid chromatographic-mass spectrometry. RESULTS: At least 1 isothiazolinone was detected in all 47 paints. However, no paint contained butyl BIT, and only 1 paint had octylisothiazolinone. The MI and BIT were found in 96% and 94% of the paints, respectively. Methylisothiazolinone ranged in concentration from 17 to 358 ppm, whereas BIT varied from 29 to 1111 ppm. Methylchloroisothiazolinone was found solely in oil-based paints. Isothiazolinones were declared in 15% of Safety Data Sheets but did not correlate with high-performance liquid chromatographic-mass spectrometry. One 'preservative-free' paint had BIT at 71.5 ppm. Paint sheen was not statistically associated with BIT or MI concentrations. Unpigmented paints and paints with volatile organic compound claims had significantly lower concentrations of MI, but not BIT. CONCLUSIONS: All paints contained at least 1 isothiazolinone. Methylisothiazolinone and BIT were the most common. Safety Data Sheets are insufficient for ascertaining isothiazolinone content in US paints"
Keywords:		"Anti-Infective Agents/*analysis Chromatography, High Pressure Liquid Mass Spectrometry Material Safety Data Sheets *Paint Thiazoles/analysis Volatile Organic Compounds;"
Notes:		"MedlineGoodier, Molly C Siegel, Paul D Zang, Lun-Yi Warshaw, Erin M eng CC999999/Intramural CDC HHS/ 2018/10/23 Dermatitis. 2018 Nov/Dec; 29(6):332-338. doi: 10.1097/DER.0000000000000410"