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Int J Mol Sci

Title:		"Chemical Diversity, Biological Activity, and Genetic Aspects of Three Ocotea Species from the Amazon"
Author(s):		da Silva JK; da Trindade R; Moreira EC; Maia JGS; Dosoky NS; Miller RS; Cseke LJ; Setzer WN;
Address:		"Programa de Pos-Graduacao em Biotecnologia, Universidade Federal do Para, 66075-900 Belem, Brazil. joycekellys@ufpa.br. Programa de Pos-Graduacao em Biotecnologia, Universidade Federal do Para, 66075-900 Belem, Brazil. rcabral@ufpa.br. Instituto de Estudos em Saude e Biologicas, Universidade Federal do Sul e Sudeste do Para, 68501-970 Maraba, Brazil. cibelle@unifesspa.edu.br. Programa de Pos-Graduacao em Recursos Naturais da Amazonia, Universidade Federal do Oeste do Para, 68035-110 Santarem, Brazil. gmaia@ufpa.br. Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA. nouradosoky@yahoo.com. Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899, USA. rsm0024@uah.edu. Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899, USA. csekel@uah.edu. Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA. wsetzer@chemistry.uah.edu"
Journal Title:		Int J Mol Sci
Year:		2017
Volume:		20170518
Issue:		5
Page Number:		-
DOI:		10.3390/ijms18051081
ISSN/ISBN:		1422-0067 (Electronic) 1422-0067 (Linking)
Abstract:		"Ocotea species present economic importance and biological activities attributed to their essential oils (EOs) and extracts. For this reason, various strategies have been developed for their conservation. The chemical compositions of the essential oils and matK DNA sequences of O. caudata, O. cujumary, and O. caniculata were subjected to comparison with data from O. floribunda, O. veraguensis, and O. whitei, previously reported. The multivariate analysis of chemical composition classified the EOs into two main clusters. Group I was characterized by the presence of alpha-pinene (9.8-22.5%) and beta-pinene (9.7-21.3%) and it includes O. caudata, O. whitei, and O. floribunda. In group II, the oils of O. cujumary and O. caniculata showed high similarity due amounts of beta-caryophyllene (22.2% and 18.9%, respectively). The EO of O. veraguensis, rich in p-cymene (19.8%), showed minor similarity among all samples. The oils displayed promising antimicrobial and cytotoxic activities against Escherichia coli (minimum inhibitory concentration (MIC) < 19.5 microg.mL(-1)) and MCF-7 cells (median inhibitory concentration (IC(50)) congruent with 65.0 microg.mL(-1)), respectively. The analysis of matK gene displayed a good correlation with the main class of chemical compounds present in the EOs. However, the matK gene data did not show correlation with specific compounds"
Keywords:		Bicyclic Monoterpenes Cymenes Escherichia coli/drug effects Humans Lauraceae/chemistry/classification/genetics MCF-7 Cells Monoterpenes/chemistry Ocotea/*chemistry/classification/*genetics Phylogeny Terpenes/*chemistry Volatile Organic Compounds/*chemistr;
Notes:		"Medlineda Silva, Joyce Kelly da Trindade, Rafaela Moreira, Edith Cibelle Maia, Jose Guilherme S Dosoky, Noura S Miller, Rebecca S Cseke, Leland J Setzer, William N eng Switzerland 2017/05/20 Int J Mol Sci. 2017 May 18; 18(5):1081. doi: 10.3390/ijms18051081"