| Title: | Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice |
| Author(s): | Choi JM; Kim SS; Choi CI; Cha HL; Oh HH; Ghil S; Lee YD; Birnbaumer L; Suh-Kim H; |
| Address: | "Department of Anatomy, Ajou University School of Medicine, Suwon 16499, South Korea; Department of Anatomy, Ajou University School of Medicine, Suwon 16499, South Korea; Department of Biomedical Sciences, The Graduate School, Ajou University School of Medicine, Suwon 16499, South Korea; Department of Life Science, Kyonggi University, Suwon 16227, South Korea; Neurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709; Institute of Biomedical Research, School of Medical Sciences, Catholic University of Argentina, C1107AFF Buenos Aires, Argentina Birnbau1@gmail.com hysuh@ajou.ac.kr. Department of Anatomy, Ajou University School of Medicine, Suwon 16499, South Korea; Department of Biomedical Sciences, The Graduate School, Ajou University School of Medicine, Suwon 16499, South Korea; Birnbau1@gmail.com hysuh@ajou.ac.kr" |
| ISSN/ISBN: | 1091-6490 (Electronic) 0027-8424 (Print) 0027-8424 (Linking) |
| Abstract: | "In mammals, initial detection of olfactory stimuli is mediated by sensory neurons in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). The heterotrimeric GTP-binding protein Go is widely expressed in the MOE and VNO of mice. Early studies indicated that Go expression in VNO sensory neurons is critical for directing social and sexual behaviors in female mice [Oboti L, et al. (2014) BMC Biol 12:31]. However, the physiological functions of Go in the MOE have remained poorly defined. Here, we examined the role of Go in the MOE using mice lacking the alpha subunit of Go Development of the olfactory bulb (OB) was perturbed in mutant mice as a result of reduced neurogenesis and increased cell death. The balance between cell types of OB interneurons was altered in mutant mice, with an increase in the number of tyrosine hydroxylase-positive interneurons at the expense of calbindin-positive interneurons. Sexual behavior toward female mice and preference for female urine odors by olfactory sensory neurons in the MOE were abolished in mutant male mice. Our data suggest that Go signaling is essential for the structural and functional integrity of the MOE and for specification of OB interneurons, which in turn are required for the transmission of pheromone signals and the initiation of mating behavior with the opposite sex" |
| Keywords: | "Animals Apoptosis/genetics Cell Count Cells, Cultured GTP-Binding Protein alpha Subunits, Gi-Go/deficiency/genetics/*metabolism Gene Deletion Interneurons/metabolism Male Mice Models, Biological Neurogenesis/genetics Olfactory Bulb/metabolism Olfactory Mu;" |
| Notes: | "MedlineChoi, Jung-Mi Kim, Sung-Soo Choi, Chan-Il Cha, Hye Lim Oh, Huy-Hyen Ghil, Sungho Lee, Young-Don Birnbaumer, Lutz Suh-Kim, Haeyoung eng Z01 ES101643/ImNIH/Intramural NIH HHS/ Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't 2016/09/15 Proc Natl Acad Sci U S A. 2016 Sep 27; 113(39):10974-9. doi: 10.1073/pnas.1613026113. Epub 2016 Sep 13" |
