| Title: | "Synthesis and biological activities of analogs of D-glucosyl-l-tyrosine, a humoral factor that stimulates transcription of the acyl-CoA binding protein in the pheromone gland of the Silkmoth, Bombyx mori" |
| Author(s): | Takahashi S; Hasumi K; Ohnishi A; Koshino H; Matsumoto S; |
| Address: | "RIKEN (The Institute of Physical and Chemical Research), Wako-shi, Saitama 351-0198, Japan. shunyat@riken.go.jp" |
| DOI: | 10.1016/j.bmc.2006.10.008 |
| ISSN/ISBN: | 0968-0896 (Print) 0968-0896 (Linking) |
| Abstract: | "beta-d-Glucosyl-O-l-tyrosine (1) is a humoral factor that stimulates transcription of the acyl-CoA binding protein (ACBP) in the pheromone gland of the Silkmoth, Bombyx mori. This paper describes stereoselective synthesis of five analogs that changed the sugar and/or amino acid part in 1 and their stimulatory activities on the ACBP transcription in the pheromone gland of B. mori. Among the analogs tested, beta-d-galactosyl-O-l-tyrosine showed a 1/5 potency compared to the activity of 1" |
| Keywords: | Animals Biological Assay Bombyx/chemistry/*drug effects/*metabolism Diazepam Binding Inhibitor/*metabolism Female Gene Expression Regulation/*drug effects Molecular Conformation Monosaccharides/*chemical synthesis/chemistry/*pharmacology Pupa/drug effects; |
| Notes: | "MedlineTakahashi, Shunya Hasumi, Keiko Ohnishi, Atsushi Koshino, Hiroyuki Matsumoto, Shogo eng Research Support, Non-U.S. Gov't England 2006/10/27 Bioorg Med Chem. 2007 Jan 1; 15(1):97-103. doi: 10.1016/j.bmc.2006.10.008. Epub 2006 Oct 10" |
