| Title: | Potential exposure to clothianidin and risk assessment of manual users of treated soil |
| Author(s): | Ren J; Tao C; Zhang L; Ning J; Mei X; She D; |
| Address: | "State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Beijing, China. Institute for the Control of Agrochemicals, Beijing, China" |
| ISSN/ISBN: | 1526-4998 (Electronic) 1526-498X (Linking) |
| Abstract: | "BACKGROUND: Treated soil is the second most prevalent application technique for all registered pesticides in China. Some developing countries also adopt this method. However, the safety of this scenario has not been reported in the literature. Experiments were therefore conducted to assess exposure using standard whole-body dosimetry and air sampling methodologies. RESULTS: Dermal deposition was the main route of exposure in this scenario. The total dermal unit exposure (UE) of operators to clothianidin-treated soil was 51.7 mg kg(-1) AI handled (SD = 20.59, n = 16), and hands accounted for 36%. Inhalation UE was 0.04 mg kg(-1) AI handled (SD = 0.02, n = 4), negligible compared with dermal exposure. Using an NOAEL (no observed adverse effect level) of 10 mg kg(-1) day(-1) , the margin of exposure was 773, i.e. greater than 100. CONCLUSION: For the first time, the scenario of treated soil exposure was assessed and was found to pose less risk than conventional pesticide application. These results can be used as a reference in pesticide management. (c) 2017 Society of Chemical Industry" |
| Keywords: | Guanidines/*adverse effects/*analysis Humans Inhalation Neonicotinoids/*adverse effects/*analysis Occupational Exposure/*adverse effects/*analysis Risk Assessment Skin/drug effects *Soil Thiazoles/*adverse effects/*analysis clothianidin dermal exposure in; |
| Notes: | "MedlineRen, JingXia Tao, ChuanJiang Zhang, LiYing Ning, Jun Mei, XiangDong She, DongMei eng England 2017/01/28 Pest Manag Sci. 2017 Sep; 73(9):1798-1803. doi: 10.1002/ps.4535. Epub 2017 Mar 7" |
