| Title: | Promising Fungicides from Allelochemicals: Synthesis of Umbelliferone Derivatives and Their Structure(-)Activity Relationships |
| Author(s): | Pan L; Lei D; Jin L; He Y; Yang Q; |
| Address: | "Chemical Engineering College, Xinjiang Agricultural University, Urumqi 830052, China. inmail911@sina.com. Department of Physiology, Preclinical School, Xinjiang Medical University, Urumqi 830011, China. leidongyu0109@163.com. Chemical Engineering College, Xinjiang Agricultural University, Urumqi 830052, China. chemkimlu@xjtu.edu.cn. Chemical Engineering College, Xinjiang Agricultural University, Urumqi 830052, China. hy941813@163.com. Chemical Engineering College, Xinjiang Agricultural University, Urumqi 830052, China. yqq1509914@sina.com" |
| DOI: | 10.3390/molecules23113002 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "Umbelliferone was discovered to be an important allelochemical in our previous study, but the contribution of its activity and structure has not yet been revealed. In this study, a series of analogues were synthesized to determine the skeleton of umbelliferone and examine its fungicidal activity. Furthermore, targeted modifications were conducted with three plant parasitic fungi to examine the lead compounds. Among those tested, compounds 2f and 10 were found to show excellent antifungal activity with an inhibitory rate over 80% at 100 ug/mL. The study proves that umbelliferone can be a promising skeleton for fungicides discovery. In addition, the primary structure(-)activity relationship provides a good guidance for the discovery of novel fungicides based on natural products in the future" |
| Keywords: | "Antifungal Agents/*chemical synthesis/*pharmacology Drug Design Fungi/*drug effects Fungicides, Industrial Microbial Sensitivity Tests Molecular Structure Pheromones/*chemistry Plants/parasitology Umbelliferones/*chemistry/*pharmacology EC50 values allelo;" |
| Notes: | "MedlinePan, Le Lei, Dongyu Jin, Lu He, Yuan Yang, Qingqing eng XJ201609/the scheme of Tianchi Talent on Doctor introduction in the Xinjiang Uygur Autonomous Region/ XJ201612/Research Foundation for Advanced Talents in Xinjiang Uygur Autonomous Region of China/ XJAU201606/the prophase- sustentation Foundation of Xinjiang agricultural university/ Switzerland 2018/11/21 Molecules. 2018 Nov 16; 23(11):3002. doi: 10.3390/molecules23113002" |
