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Proc Natl Acad Sci U S A

Title:		A Trojan horse mechanism of bacterial pathogenesis against nematodes
Author(s):		Niu Q; Huang X; Zhang L; Xu J; Yang D; Wei K; Niu X; An Z; Bennett JW; Zou C; Yang J; Zhang KQ;
Address:		"Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
Journal Title:		Proc Natl Acad Sci U S A
Year:		2010
Volume:		20100823
Issue:		38
Page Number:		16631 - 16636
DOI:		10.1073/pnas.1007276107
ISSN/ISBN:		1091-6490 (Electronic) 0027-8424 (Print) 0027-8424 (Linking)
Abstract:		"Understanding the mechanisms of host-pathogen interaction can provide crucial information for successfully manipulating their relationships. Because of its genetic background and practical advantages over vertebrate model systems, the nematode Caenorhabditis elegans model has become an attractive host for studying microbial pathogenesis. Here we report a 'Trojan horse' mechanism of bacterial pathogenesis against nematodes. We show that the bacterium Bacillus nematocida B16 lures nematodes by emitting potent volatile organic compounds that are much more attractive to worms than those from ordinary dietary bacteria. Seventeen B. nematocida-attractant volatile organic compounds are identified, and seven are individually confirmed to lure nematodes. Once the bacteria enter the intestine of nematodes, they secrete two proteases with broad substrate ranges but preferentially target essential intestinal proteins, leading to nematode death. This Trojan horse pattern of bacterium-nematode interaction enriches our understanding of microbial pathogenesis"
Keywords:		Animals Bacillus/*pathogenicity/physiology Caenorhabditis elegans/*microbiology/physiology Host-Pathogen Interactions/*physiology Intestines/microbiology Odorants Peptide Hydrolases/metabolism Soil/parasitology Virulence/physiology Virulence Factors/metab;
Notes:		"MedlineNiu, Qiuhong Huang, Xiaowei Zhang, Lin Xu, Jianping Yang, Dongmei Wei, Kangbi Niu, Xuemei An, Zhiqiang Bennett, Joan Wennstrom Zou, Chenggang Yang, Jinkui Zhang, Ke-Qin eng 27398C0007/ES/NIEHS NIH HHS/ Research Support, Non-U.S. Gov't 2010/08/25 Proc Natl Acad Sci U S A. 2010 Sep 21; 107(38):16631-6. doi: 10.1073/pnas.1007276107. Epub 2010 Aug 23"