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Proc Natl Acad Sci U S A

Title:		A tale of two copies: Evolutionary trajectories of moth pheromone receptors
Author(s):		Li Z; Capoduro R; Bastin-Heline L; Zhang S; Sun D; Lucas P; Dabir-Moghaddam D; Francois MC; Liu Y; Wang G; Jacquin-Joly E; Montagne N; Meslin C;
Address:		"Sorbonne Universite, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, CNRS, Institut de Recherche pour le Developpement, Universite Paris-Est-Creteil-Val-de-Marne, Universite Paris Cite, Institut d'Ecologie et des Sciences de l'Environnement de Paris, Versailles 78026, France. Laboratoire Reproduction et Developpement des plantes, UMR 5667, Ecole Normale Superieure de Lyon, CNRS, Lyon F-69364, France. State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China"
Journal Title:		Proc Natl Acad Sci U S A
Year:		2023
Volume:		20230508
Issue:		20
Page Number:		e2221166120 -
DOI:		10.1073/pnas.2221166120
ISSN/ISBN:		1091-6490 (Electronic) 0027-8424 (Print) 0027-8424 (Linking)
Abstract:		"Pheromone communication is an essential component of reproductive isolation in animals. As such, evolution of pheromone signaling can be linked to speciation. For example, the evolution of sex pheromones is thought to have played a major role in the diversification of moths. In the crop pests Spodoptera littoralis and S. litura, the major component of the sex pheromone blend is (Z,E)-9,11-tetradecadienyl acetate, which is lacking in other Spodoptera species. It indicates that a major shift occurred in their common ancestor. It has been shown recently in S. littoralis that this compound is detected with high specificity by an atypical pheromone receptor, named SlitOR5. Here, we studied its evolutionary history through functional characterization of receptors from different Spodoptera species. SlitOR5 orthologs in S. exigua and S. frugiperda exhibited a broad tuning to several pheromone compounds. We evidenced a duplication of OR5 in a common ancestor of S. littoralis and S. litura and found that in these two species, one duplicate is also broadly tuned while the other is specific to (Z,E)-9,11-tetradecadienyl acetate. By using ancestral gene resurrection, we confirmed that this narrow tuning evolved only in one of the two copies issued from the OR5 duplication. Finally, we identified eight amino acid positions in the binding pocket of these receptors whose evolution has been responsible for narrowing the response spectrum to a single ligand. The evolution of OR5 is a clear case of subfunctionalization that could have had a determinant impact in the speciation process in Spodoptera species"
Keywords:		"Animals;Animals *Moths/genetics/metabolism Receptors, Pheromone/genetics/metabolism *Sex Attractants/metabolism Spodoptera/genetics Pheromones/genetics/metabolism ancestral gene resurrection evolution pheromone receptor;"
Notes:		"MedlineLi, Zibo Capoduro, Remi Bastin-Heline, Lucie Zhang, Sai Sun, Dongdong Lucas, Philippe Dabir-Moghaddam, Diane Francois, Marie-Christine Liu, Yang Wang, Guirong Jacquin-Joly, Emmanuelle Montagne, Nicolas Meslin, Camille eng Research Support, Non-U.S. Gov't 2023/05/08 Proc Natl Acad Sci U S A. 2023 May 16; 120(20):e2221166120. doi: 10.1073/pnas.2221166120. Epub 2023 May 8"