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Curr Opin Cell Biol

Title:		The proliferation of MAP kinase signaling pathways in yeast
Author(s):		Levin DE; Errede B;
Address:		"Department of Biochemistry, Johns Hopkins University School of Public Health, Baltimore, MD 21205, USA"
Journal Title:		Curr Opin Cell Biol
Year:		1995
Volume:		7
Issue:		2
Page Number:		197 - 202
DOI:		10.1016/0955-0674(95)80028-x
ISSN/ISBN:		0955-0674 (Print) 0955-0674 (Linking)
Abstract:		"Mitogen-activated protein kinases function in at least five, physiologically distinct, signaling pathways in yeast. These include pathways that mediate response to mating pheromone, pseudohyphal development and invasive growth, cell integrity, sporulation, and response to high extracellular osmolarity. These kinases and their upstream activating kinases comprise signaling modules that, in at least some cases, exist as multiprotein complexes. Studies during the past year have revealed that the Ste5 protein of the mating pheromone response pathway serves as a scaffold to promote interactions among the protein kinases in this pathway, and to prevent their interaction with kinases of other modules"
Keywords:		Enzyme Activation Glycerol/metabolism Mitogens Osmolar Concentration Protein Kinase C/physiology Protein Kinases/*metabolism Saccharomyces cerevisiae/*enzymology Signal Transduction/*physiology;
Notes:		"MedlineLevin, D E Errede, B eng R01 GM048533/GM/NIGMS NIH HHS/ Review England 1995/04/01 Curr Opin Cell Biol. 1995 Apr; 7(2):197-202. doi: 10.1016/0955-0674(95)80028-x"