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J Fungi (Basel)

Title:		In Vitro Systems for Toxicity Evaluation of Microbial Volatile Organic Compounds on Humans: Current Status and Trends
Author(s):		Cerimi K; Jackel U; Meyer V; Daher U; Reinert J; Klar S;
Address:		"Unit 4.7 Biological Agents, Federal Institute for Occupational Safety and Health, Noldnerstrasse 40-42, 10317 Berlin, Germany. Chair of Applied and Molecular Microbiology, Institute of Biotechnology, Technische Universitat Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany. BIH Center for Regenerative Therapies (BCRT), BIH Stem Cell Core Facility, Berlin Institute of Health, Charite-Universitatsmedizin, 13353 Berlin, Germany"
Journal Title:		J Fungi (Basel)
Year:		2022
Volume:		20220113
Issue:		1
Page Number:		-
DOI:		10.3390/jof8010075
ISSN/ISBN:		2309-608X (Electronic) 2309-608X (Linking)
Abstract:		"Microbial volatile organic compounds (mVOC) are metabolic products and by-products of bacteria and fungi. They play an important role in the biosphere: They are responsible for inter- and intra-species communication and can positively or negatively affect growth in plants. But they can also cause discomfort and disease symptoms in humans. Although a link between mVOCs and respiratory health symptoms in humans has been demonstrated by numerous studies, standardized test systems for evaluating the toxicity of mVOCs are currently not available. Also, mVOCs are not considered systematically at regulatory level. We therefore performed a literature survey of existing in vitro exposure systems and lung models in order to summarize the state-of-the-art and discuss their suitability for understanding the potential toxic effects of mVOCs on human health. We present a review of submerged cultivation, air-liquid-interface (ALI), spheroids and organoids as well as multi-organ approaches and compare their advantages and disadvantages. Furthermore, we discuss the limitations of mVOC fingerprinting. However, given the most recent developments in the field, we expect that there will soon be adequate models of the human respiratory tract and its response to mVOCs"
Keywords:		In vitro toxicology fingerprinting in vitro exposure system microbial volatile organic compounds organoids respiratory health;
Notes:		"PubMed-not-MEDLINECerimi, Kustrim Jackel, Udo Meyer, Vera Daher, Ugarit Reinert, Jessica Klar, Stefanie eng Review Switzerland 2022/01/21 J Fungi (Basel). 2022 Jan 13; 8(1):75. doi: 10.3390/jof8010075"