| Title: | Personal Exposure to Total VOC Is Associated With Symptoms of Atopic Dermatitis in Schoolchildren |
| Author(s): | Ha EK; Kim JH; Park D; Lee E; Lee SW; Jee HM; Shin YH; Han MY; |
| Address: | "Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea. Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea. Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea. Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea. Department of Data Science, Sejong University College of Software Convergence, Seoul, Korea. Department of Precision Medicine, Sungkyunkwan University School of medicine, Suwon, Korea. Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea. Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea. drmesh@gmail.com" |
| ISSN/ISBN: | 1598-6357 (Electronic) 1011-8934 (Print) 1011-8934 (Linking) |
| Abstract: | "BACKGROUND: The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren. METHODS: Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children. RESULTS: Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with positive SCORAD index values (defined as SCORAD >/= 5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and positive SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and positive SCORAD results. CONCLUSION: Personal exposure to VOCs, as indicated by urinary levels of VOC metabolites, was associated with presence of atopic dermatitis and the SCORAD index value" |
| Keywords: | "*Asthma Child *Dermatitis, Atopic/diagnosis *Eczema Humans *Hypersensitivity Severity of Illness Index *Volatile Organic Compounds Atopic Dermatitis Urinary Metabolite Volatile Organic Compounds;" |
| Notes: | "MedlineHa, Eun Kyo Kim, Ju Hee Park, Dawon Lee, Eun Lee, Seung Won Jee, Hye Mi Shin, Youn Ho Han, Man Yong eng SAP2017/Seongnam Atopy Project for Children Happiness/Korea NRF2020R1F1A1076452/National Research Foundation of Korea/Korea Korea (South) 2022/03/01 J Korean Med Sci. 2022 Feb 28; 37(8):e63. doi: 10.3346/jkms.2022.37.e63" |
