| Title: | Relative toxicity for indoor semi volatile organic compounds based on neuronal death |
| Author(s): | Fournier K; Baumont E; Glorennec P; Bonvallot N; |
| Address: | "EHESP School of Public Health, Sorbonne Paris Cite, Avenue du Professeur Leon Bernard, 35043 Rennes Cedex, France; INSERM UMR1085 IRSET (Research Institute in Environmental and Occupational Health), Rennes, France. Electronic address: kevin.fournier01@gmail.com. EHESP School of Public Health, Sorbonne Paris Cite, Avenue du Professeur Leon Bernard, 35043 Rennes Cedex, France; INSERM UMR1085 IRSET (Research Institute in Environmental and Occupational Health), Rennes, France. Electronic address: emmanuel.baumont@cstb.fr. EHESP School of Public Health, Sorbonne Paris Cite, Avenue du Professeur Leon Bernard, 35043 Rennes Cedex, France; INSERM UMR1085 IRSET (Research Institute in Environmental and Occupational Health), Rennes, France. Electronic address: philippe.glorennec@ehesp.fr. EHESP School of Public Health, Sorbonne Paris Cite, Avenue du Professeur Leon Bernard, 35043 Rennes Cedex, France; INSERM UMR1085 IRSET (Research Institute in Environmental and Occupational Health), Rennes, France. Electronic address: nathalie.bonvallot@ehesp.fr" |
| DOI: | 10.1016/j.toxlet.2017.07.875 |
| ISSN/ISBN: | 1879-3169 (Electronic) 0378-4274 (Linking) |
| Abstract: | "BACKGROUND: Semi Volatile Organic Compounds (SVOCs) are contaminants commonly found in dwellings as a result of their use as plasticizers, flame retardants, or pesticides in building materials and consumer products. Many SVOCs are suspected of being neurotoxic, based on mammal experimentation (impairment of locomotor activity, spatial learning/memory or behavioral changes), raising the question of cumulative risk assessment. The aim of this work is to estimate the relative toxicity of such SVOCs, based on neuronal death. METHOD: SVOCs fulfilling the following conditions were included: detection frequency >10% in dwellings, availability of data on effects or mechanism of action for neurotoxicity, and availability of dose-response relationships based on cell viability assays as a proxy of neuronal death. Benchmark concentration values (BMC) were estimated using a Hill model, and compared to assess relative toxicity. RESULTS: Of the 58 SVOCs selected, 28 were suspected of being neurotoxic in mammals, and 21 have been documented as inducing a decrease in cell viability in vitro. 13 have at least one dose-response relationship that can be used to derive a BMC based on a 10% fall in neuronal viability. Based on this in vitro endpoint, PCB-153 appeared to be the most toxic compound, having the lowest BMC(10) (0.072muM) and diazinon the least toxic compound, having the highest BMC(10) (94.35muM). We showed that experimental designs (in particular choice of cell lines) had a significant influence on BMC calculation. CONCLUSION: For the first time, the relative in vitro toxicity of 13 indoor contaminants belonging to different chemical families has been assessed on the basis of neuronal cell viability. Lack of comparable toxicity datasets limits the number of SVOCs that can be included. More standardized protocols in terms of cell lines, species and exposure duration should be developed with a view to cumulative risk assessment" |
| Keywords: | "Air Pollutants/*toxicity *Air Pollution, Indoor Benchmarking Cell Death/drug effects Cell Line Dose-Response Relationship, Drug Environmental Monitoring/*methods/standards Humans Inhalation Exposure/*adverse effects Models, Statistical Neurons/*drug effec;" |
| Notes: | "MedlineFournier, Kevin Baumont, Emmanuel Glorennec, Philippe Bonvallot, Nathalie eng Comparative Study Netherlands 2017/07/16 Toxicol Lett. 2017 Sep 5; 279:33-42. doi: 10.1016/j.toxlet.2017.07.875. Epub 2017 Jul 12" |
