| Title: | Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast |
| Author(s): | Cvrckova F; De Virgilio C; Manser E; Pringle JR; Nasmyth K; |
| Address: | "Institute of Molecular Pathology (IMP), Wien, Austria" |
| ISSN/ISBN: | 0890-9369 (Print) 0890-9369 (Linking) |
| Abstract: | "The yeast Ste20 protein kinase is involved in pheromone response. Mammalian homologs of Ste20 exist, but their function remains unknown. We identified a novel yeast STE20 homolog, CLA4, in a screen for mutations lethal in the absence of the G1 cyclins Cln1 and Cln2. Cla4 is involved in budding and cytokinesis and interacts with Cdc42, a GTPase required for polarized cell growth. Despite a cytokinesis defect, cla4 mutants are viable. However, double cla4 ste20 mutants cannot maintain septin rings at the bud neck and cannot undergo cytokinesis. Mutations in CDC12, which encodes one of the septins, were found in the same screen. Cla4 and Ste20 kinases apparently share a function in localizing cell growth with respect to the septin ring" |
| Keywords: | "Amino Acid Sequence Cell Compartmentation/physiology Cell Cycle Proteins/genetics Cell Division/physiology Cell Polarity/physiology Cyclins/genetics/metabolism Fungal Proteins/*genetics GTP Phosphohydrolases/metabolism Genes, Fungal/*genetics Intracellula;" |
| Notes: | "MedlineCvrckova, F De Virgilio, C Manser, E Pringle, J R Nasmyth, K eng GM 31006/GM/NIGMS NIH HHS/ Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1995/08/01 Genes Dev. 1995 Aug 1; 9(15):1817-30. doi: 10.1101/gad.9.15.1817" |
