| Title: | Treatment of vacutainers for use in the analysis of volatile organic compounds in human blood at the low parts-per-trillion level |
| Author(s): | Cardinali FL; McCraw JM; Ashley DL; Bonin M; Wooten J; |
| Address: | "Division of Environmental Health Laboratory Sciences, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30341, USA" |
| DOI: | 10.1093/chromsci/33.10.557 |
| ISSN/ISBN: | 0021-9665 (Print) 0021-9665 (Linking) |
| Abstract: | "Vacutainers that are routinely used for blood collection contain significant amounts of volatile organic compounds (VOCs). These VOCs interfere with the low parts-per-trillion analysis of VOCs in whole blood either by causing false positives or by masking the presence of VOCs because of high background levels. Benzene, bromoform, ethylbenzene, m/p-xylene, o-xylene, styrene, and various hydrocarbons are the most significant sources of VOC contamination present in the vacutainers. A method of removing VOCs from 10-mL gray-top vacutainers is presented. This method uses a combination of heat and vacuum to reduce the VOCs to levels compatible with low parts-per-trillion analysis of VOCs in whole blood" |
| Keywords: | Blood Specimen Collection/*instrumentation False Positive Reactions Gas Chromatography-Mass Spectrometry Humans Hydrocarbons/analysis/*blood; |
| Notes: | "MedlineCardinali, F L McCraw, J M Ashley, D L Bonin, M Wooten, J eng 1995/10/01 J Chromatogr Sci. 1995 Oct; 33(10):557-60. doi: 10.1093/chromsci/33.10.557" |
