| Title: | "Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples" |
| Author(s): | Astolfi M; Rispoli G; Anania G; Artioli E; Nevoso V; Zonta G; Malagu C; |
| Address: | "Department of Physics and Earth Sciences, University of Ferrara, 44122 Ferrara, Italy. SCENT S.r.l (SME company), Via Quadrifoglio 11, 44124 Ferrara, Italy. Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy. Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy" |
| DOI: | 10.3390/molecules26020466 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "User-friendly, low-cost equipment for preventive screening of severe or deadly pathologies are one of the most sought devices by the National Health Services, as they allow early disease detection and treatment, often avoiding its degeneration. In recent years more and more research groups are developing devices aimed at these goals employing gas sensors. Here, nanostructured chemoresistive metal oxide (MOX) sensors were employed in a patented prototype aimed to detect volatile organic compounds (VOCs), exhaled by blood samples collected from patients affected by colorectal cancer and from healthy subjects as a control. Four sensors, carefully selected after many years of laboratory tests on biological samples (cultured cells, human stools, human biopsies, etc.), were based here on various percentages of tin, tungsten, titanium, niobium, tantalum and vanadium oxides. Sensor voltage responses were statistically analyzed also with the receiver operating characteristic (ROC) curves, that allowed the identification of the cut-off discriminating between healthy and tumor affected subjects for each sensor, leading to an estimate of sensitivity and specificity parameters. ROC analysis demonstrated that sensors employing tin and titanium oxides decorated with gold nanoparticles gave sensitivities up to 80% yet with a specificity of 70%" |
| Keywords: | "Adult Colorectal Neoplasms/*blood Female Humans Male Metal Nanoparticles/*chemistry *Microscopy, Electrochemical, Scanning Niobium/*chemistry Tantalum/*chemistry Tin/*chemistry Vanadium/*chemistry Volatile Organic Compounds/*blood blood chemoresistivity c;Neuroscience;" |
| Notes: | "MedlineAstolfi, Michele Rispoli, Giorgio Anania, Gabriele Artioli, Elena Nevoso, Veronica Zonta, Giulia Malagu, Cesare eng FAR 2016 - 2020; FIR 2016/University of Ferrara/ Private Funding/SCENT S.r.l./ Clinical Trial Switzerland 2021/01/23 Molecules. 2021 Jan 17; 26(2):466. doi: 10.3390/molecules26020466" |
