| Title: | Estimating Acute Cardiorespiratory Effects of Ambient Volatile Organic Compounds |
| Author(s): | Ye D; Klein M; Chang HH; Sarnat JA; Mulholland JA; Edgerton ES; Winquist A; Tolbert PE; Sarnat SE; |
| Address: | "From the aDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA; bDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA; cDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA; dSchool of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA; and eAtmospheric Research & Analysis, Inc., Cary, NC" |
| DOI: | 10.1097/EDE.0000000000000607 |
| ISSN/ISBN: | 1531-5487 (Electronic) 1044-3983 (Print) 1044-3983 (Linking) |
| Abstract: | "BACKGROUND: The health effects of ambient volatile organic compounds (VOCs) have received less attention in epidemiologic studies than other commonly measured ambient pollutants. In this study, we estimated acute cardiorespiratory effects of ambient VOCs in an urban population. METHODS: Daily concentrations of 89 VOCs were measured at a centrally-located ambient monitoring site in Atlanta and daily counts of emergency department visits for cardiovascular diseases and asthma in the five-county Atlanta area were obtained for the 1998-2008 period. To understand the health effects of the large number of species, we grouped these VOCs a priori by chemical structure and estimated the associations between VOC groups and daily counts of emergency department visits in a time-series framework using Poisson regression. We applied three analytic approaches to estimate the VOC group effects: an indicator pollutant approach, a joint effect analysis, and a random effect meta-analysis, each with different assumptions. We performed sensitivity analyses to evaluate copollutant confounding. RESULTS: Hydrocarbon groups, particularly alkenes and alkynes, were associated with emergency department visits for cardiovascular diseases, while the ketone group was associated with emergency department visits for asthma. CONCLUSIONS: The associations observed between emergency department visits for cardiovascular diseases and alkenes and alkynes may reflect the role of traffic exhaust, while the association between asthma visits and ketones may reflect the role of secondary organic compounds. The different patterns of associations we observed for cardiovascular diseases and asthma suggest different modes of action of these pollutants or the mixtures they represent" |
| Keywords: | "Adolescent Adult Aged Air Pollution/*statistics & numerical data *Alkenes *Alkynes Asthma/*epidemiology Cardiovascular Diseases/*epidemiology Child Child, Preschool Emergency Service, Hospital/*statistics & numerical data Environmental Exposure/statistics;" |
| Notes: | "MedlineYe, Dongni Klein, Mitchel Chang, Howard H Sarnat, Jeremy A Mulholland, James A Edgerton, Eric S Winquist, Andrea Tolbert, Paige E Sarnat, Stefanie Ebelt eng P30 ES019776/ES/NIEHS NIH HHS/ R01 ES011294/ES/NIEHS NIH HHS/ 2016/12/17 Epidemiology. 2017 Mar; 28(2):197-206. doi: 10.1097/EDE.0000000000000607" |
