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Nat Commun

Title:		Integrating pheromonal and spatial information in the amygdalo-hippocampal network
Author(s):		Villafranca-Faus M; Vila-Martin ME; Esteve D; Merino E; Teruel-Sanchis A; Cervera-Ferri A; Martinez-Ricos J; Lloret A; Lanuza E; Teruel-Marti V;
Address:		"Neuronal Circuits Laboratory, Dept. of Anatomy and Human Embriology, Faculty of Medicine, University de Valencia, Valencia, Spain. Laboratori de Neuranatomia Funcional, Dept. de Biologia Cel.lular, Fac. CC. Biologiques, Universitat de Valencia, Valencia, Spain. Department of Physiology, Faculty of Medicine, University of Valencia, Health Research Institute INCLIVA, CIBERFES, Valencia, Spain. Neuronal Circuits Laboratory, Dept. of Anatomy and Human Embriology, Faculty of Medicine, University de Valencia, Valencia, Spain. enrique.lanuza@uv.es. Laboratori de Neuranatomia Funcional, Dept. de Biologia Cel.lular, Fac. CC. Biologiques, Universitat de Valencia, Valencia, Spain. enrique.lanuza@uv.es. Neuronal Circuits Laboratory, Dept. of Anatomy and Human Embriology, Faculty of Medicine, University de Valencia, Valencia, Spain. vicent.teruel@uv.es"
Journal Title:		Nat Commun
Year:		2021
Volume:		20210906
Issue:		1
Page Number:		5286 -
DOI:		10.1038/s41467-021-25442-5
ISSN/ISBN:		2041-1723 (Electronic) 2041-1723 (Linking)
Abstract:		"Vomeronasal information is critical in mice for territorial behavior. Consequently, learning the territorial spatial structure should incorporate the vomeronasal signals indicating individual identity into the hippocampal cognitive map. In this work we show in mice that navigating a virtual environment induces synchronic activity, with causality in both directionalities, between the vomeronasal amygdala and the dorsal CA1 of the hippocampus in the theta frequency range. The detection of urine stimuli induces synaptic plasticity in the vomeronasal pathway and the dorsal hippocampus, even in animals with experimentally induced anosmia. In the dorsal hippocampus, this plasticity is associated with the overexpression of pAKT and pGSK3beta. An amygdalo-entorhino-hippocampal circuit likely underlies this effect of pheromonal information on hippocampal learning. This circuit likely constitutes the neural substrate of territorial behavior in mice, and it allows the integration of social and spatial information"
Keywords:		"Amygdala/cytology/*physiology Animals Anosmia/genetics/metabolism/physiopathology Behavior, Animal CA1 Region, Hippocampal/cytology/*physiology Female Gene Expression Regulation Glycogen Synthase Kinase 3 beta/*genetics/metabolism Learning/physiology Male;"
Notes:		"MedlineVillafranca-Faus, Maria Vila-Martin, Manuel Esteban Esteve, Daniel Merino, Esteban Teruel-Sanchis, Anna Cervera-Ferri, Ana Martinez-Ricos, Joana Lloret, Ana Lanuza, Enrique Teruel-Marti, Vicent eng Research Support, Non-U.S. Gov't England 2021/09/08 Nat Commun. 2021 Sep 6; 12(1):5286. doi: 10.1038/s41467-021-25442-5"