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J Pharm Biomed Anal

Title:		Double-bed-type extraction needle packed with activated-carbon-based sorbents for very volatile organic compounds
Author(s):		Ueta I; Samsudin EL; Mizuguchi A; Takeuchi H; Shinki T; Kawakubo S; Saito Y;
Address:		"Department of Applied Chemistry, University of Yamanashi, 4-3-11 Takeda, Kofu 400-8511, Japan. Electronic address: iueta@yamanashi.ac.jp"
Journal Title:		J Pharm Biomed Anal
Year:		2014
Volume:		20131005
Issue:
Page Number:		423 - 428
DOI:		10.1016/j.jpba.2013.09.028
ISSN/ISBN:		1873-264X (Electronic) 0731-7085 (Linking)
Abstract:		"A novel needle-type sample preparation device was developed for the determination of very volatile organic compounds (VVOCs) in gaseous samples by gas chromatography-mass spectrometry (GC-MS). Two types of activated-carbon-based sorbents, Carbopack X and a carbon molecular sieve (CMS), were investigated as the extraction medium. A double-bed-type extraction needle showed successful extraction and desorption performance for all investigated VVOCs, including acetaldehyde, isoprene, pentane, acetone, and ethanol. Sensitive and reliable determination of VVOCs was achieved by systematically optimizing several desorption conditions. In addition, the effects of sample humidity on the extraction and desorption of analytes were investigated with the needle-type extraction devices. Only the CMS packed extraction needle was adversely affected by sample humidity during the desorption process; on the other hand the double-bed-type extraction needle was unaffected by sample humidity. Finally, the developed double-bed-type extraction needle was successfully applied to the analysis of breath VVOCs of healthy subjects"
Keywords:		"Acetaldehyde/chemistry Adsorption Breath Tests/instrumentation/*methods Carbon/chemistry Chemistry, Pharmaceutical Gas Chromatography-Mass Spectrometry Gases Healthy Volunteers Humans Limit of Detection *Needles Temperature Volatile Organic Compounds/*ana;"
Notes:		"MedlineUeta, Ikuo Samsudin, Emi Liana Mizuguchi, Ayako Takeuchi, Hayato Shinki, Takumi Kawakubo, Susumu Saito, Yoshihiro eng Research Support, Non-U.S. Gov't England 2013/11/02 J Pharm Biomed Anal. 2014 Jan; 88:423-8. doi: 10.1016/j.jpba.2013.09.028. Epub 2013 Oct 5"