| Title: | The association of specific industry-related air pollution with occurrence of chronic diseases: A register-based study |
| Author(s): | Bergstra AD; Been JV; Burdorf A; |
| Address: | "Department of Public Health, Erasmus MC, University Medical Centre, PO Box 2040, 3000CA, Rotterdam, the Netherlands; The Zeeland Public Health Service, PO Box 345, 4460AS, Goes, the Netherlands. Electronic address: arnold.bergstra@ggdzeeland.nl. Department of Public Health, Erasmus MC, University Medical Centre, PO Box 2040, 3000CA, Rotterdam, the Netherlands; Department of Paediatrics, Erasmus MC - Sophia Children's Hospital, University Medical Centre Rotterdam, PO Box 2060, 3000CB, Rotterdam, the Netherlands. Department of Public Health, Erasmus MC, University Medical Centre, PO Box 2040, 3000CA, Rotterdam, the Netherlands" |
| DOI: | 10.1016/j.envres.2022.112872 |
| ISSN/ISBN: | 1096-0953 (Electronic) 0013-9351 (Linking) |
| Abstract: | "Air pollution may contribute to onset and progression of chronic diseases such as cardiovascular and respiratory diseases. Most studies have focused on the contribution of traffic-related exposure to PM(10) or PM(2.5). Our aim was to investigate the association of different components of industry-related air pollution on the occurrence of chronic diseases. A register-based repeated cross-sectional study was conducted among 89,714 subjects (2012) with 536,599 annual observations (2012-2017) living in the vicinity of a large industrial area in the Netherlands. Information from the dispensed medication registration was linked with a dispersion model to characterize annual individual-level exposure of all subjects at place of residence. Associations between annual exposure (concentration and duration) to particulate matter (PM(10)), nitrogen oxides (NO(X)), sulphur dioxide (SO(2)), and volatile organic compounds (VOC) with annual dispensed medication for cardiovascular diseases, respiratory diseases, diabetes mellitus, and inflammatory conditions were investigated by multivariate logistic regression analysis with generalized estimating equations (GEE) while controlling for confounders. Exposure to PM(10) and to NO(X) (per mug/m(3)) were significantly associated with medication for cardiovascular diseases (OR 1.06, 95CI% 1.06-1.06 and OR 1.01, 95%CI 1.01-1.01 respectively). Exposures to PM(10) and SO(2) (per mug/m(3)) were significantly associated with medication for inflammatory conditions (OR 1.05, 95%CI 1.00-1.09 and OR 1.07, 95%CI 1.01-1.14 respectively). Exposure to SO(2) was inversely associated with respiratory diseases (OR 0.91, 95%CI 0.86-0.97). Except for inflammatory conditions, exposure duration (years) was significantly associated with the other three chronic diseases (OR varying from 1.01 to 1.03). This study indicates that specific air pollution components caused by industry may contribute to the occurrence of cardiovascular diseases, respiratory diseases, diabetes mellitus, and inflammatory conditions" |
| Keywords: | *Air Pollutants/analysis/toxicity *Air Pollution/adverse effects/analysis Chronic Disease/epidemiology Cross-Sectional Studies Environmental Exposure/adverse effects/analysis Humans Netherlands/epidemiology Nitrogen Dioxide/adverse effects/analysis Partic; |
| Notes: | "MedlineBergstra, Arnold D Been, Jasper V Burdorf, Alex eng Research Support, Non-U.S. Gov't Netherlands 2022/02/09 Environ Res. 2022 Jun; 209:112872. doi: 10.1016/j.envres.2022.112872. Epub 2022 Feb 5" |
