| Title: | Effect of putative pheromones on the electrical activity of the human vomeronasal organ and olfactory epithelium |
| Author(s): | Monti-Bloch L; Grosser BI; |
| Address: | "Department of Psychiatry, School of Medicine, University of Utah, Salt Lake City 84108" |
| Journal Title: | J Steroid Biochem Mol Biol |
| DOI: | 10.1016/0960-0760(91)90255-4 |
| ISSN/ISBN: | 0960-0760 (Print) 0960-0760 (Linking) |
| Abstract: | "The summated receptor potential was recorded from the vomeronasal organ (VNO) and olfactory epithelium (OE) of 49 human subjects of both sexes (18 to 55 years old) using surface non-polarizable silver-silver chloride electrodes. 15-25 pg of human putative pheromones, clove oil and a diluent were administered to the VNO or the OE in 0.3-1 s pulses from a 0.05 mm dia cannula connected to a multichannel delivery system. Local stimulation of the VNO produces negative potentials of 1.8-11.6 mV showing adaptation. Responses are not obtained when the recording electrode is placed in the nasal respiratory mucosa. Pheromone ER-830 significantly stimulates the male VNO (P less than 0.01; n = 20), while ER-670 produces a significant effect on female subjects (P less than 0.001; n = 20). The other pheromones tested do not show significantly different effects in both male and female (P greater than 0.1). Similar quantities of odorant or diluent produce an insignificant effect on the VNO. Stimulation of the OE with clove oil produces depolarization of 12.3 +/- 3.9 mV, while pheromones do not show a significant effect. Our results show that the VNO is a functional organ in adult humans having receptor sites for human putative pheromones" |
| Keywords: | Adolescent Adult Chemoreceptor Cells/*drug effects Electrophysiology/methods Female Humans Male Membrane Potentials/drug effects Middle Aged Nasal Septum/*drug effects Olfactory Mucosa/*drug effects Olfactory Pathways/*drug effects Pheromones/*pharmacolog; |
| Notes: | "MedlineMonti-Bloch, L Grosser, B I eng England 1991/10/01 J Steroid Biochem Mol Biol. 1991 Oct; 39(4B):573-82. doi: 10.1016/0960-0760(91)90255-4" |
