| Title: | Mate and fuse: how yeast cells do it |
| Author(s): | Merlini L; Dudin O; Martin SG; |
| Address: | "Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne 1015, Switzerland" |
| ISSN/ISBN: | 2046-2441 (Electronic) 2046-2441 (Linking) |
| Abstract: | "Many cells are able to orient themselves in a non-uniform environment by responding to localized cues. This leads to a polarized cellular response, where the cell can either grow or move towards the cue source. Fungal haploid cells secrete pheromones to signal mating, and respond by growing a mating projection towards a potential mate. Upon contact of the two partner cells, these fuse to form a diploid zygote. In this review, we present our current knowledge on the processes of mating signalling, pheromone-dependent polarized growth and cell fusion in Saccharomyces cerevisiae and Schizosaccharomyces pombe, two highly divergent ascomycete yeast models. While the global architecture of the mating response is very similar between these two species, they differ significantly both in their mating physiologies and in the molecular connections between pheromone perception and downstream responses. The use of both yeast models helps enlighten both conserved solutions and species-specific adaptations to a general biological problem" |
| Keywords: | Cell Fusion Cyclin-Dependent Kinases/metabolism Mitogen-Activated Protein Kinases/metabolism Pheromones Saccharomyces cerevisiae/*physiology Saccharomyces cerevisiae Proteins/metabolism Schizosaccharomyces/physiology Signal Transduction; |
| Notes: | "MedlineMerlini, Laura Dudin, Omaya Martin, Sophie G eng 260493/ERC_/European Research Council/International Research Support, Non-U.S. Gov't Review England 2013/03/08 Open Biol. 2013 Mar 6; 3(3):130008. doi: 10.1098/rsob.130008" |
