| Title: | Enhanced in vivo IgE production and T cell polarization toward the type 2 phenotype in association with indoor exposure to VOC: results of the LARS study |
| Author(s): | Lehmann I; Rehwagen M; Diez U; Seiffart A; Rolle-Kampczyk U; Richter M; Wetzig H; Borte M; Herbarth O; Leipzig Allergy Risk Children S; |
| Address: | "UFZ-Centre for Environmental Research Leipzig-Halle, Department of Human Exposure Research and Epidemiology, Permoserstrasse 15, D-04318 Leipzig, Germany. ilehmann@expo.ufz.de" |
| ISSN/ISBN: | 1438-4639 (Print) 1438-4639 (Linking) |
| Abstract: | "The association between indoor exposure to volatile organic compounds (VOC), prevalence of allergic sensitization and cytokine secretion profile of peripheral T cells was studied in 3 year old children of the LARS study (Leipzig Allergy Risk Children Study) to investigate the role of VOC exposure as a risk factor for the development of atopic disease. Indoor VOC exposure was measured over a period of 4 weeks in infants' bedrooms using a passive sampling system. Specific IgE antibodies to food, indoor and outdoor allergens were measured by the Pharmacia CAP system and correlated to VOC exposure (n = 120). In addition, cytokine producing peripheral T cells (interleukin(IL)-4, interferon(IFN)-gamma) were measured in a subgroup of 28 children by means of intracellular cytokine staining. For the first time we were able to show that exposure to alkanes (C6, C9, C10) and aromatic compounds (toluene, o-xylene, m + p-xylene, 2-, 3- and 4-ethyl-toluene, chlorobenzene) may contribute to the risk of allergic sensitization to the food allergens milk and egg white (Odds ratios between 5.7 and 11.2). Moreover, significantly reduced numbers of CD3+/CD8+ peripheral T cells were found in children exposed to alkanes (C9-C13), naphthalene and chlorobenzene. Exposure to benzene, ethylbenzene and chlorobenzene was associated with higher percentages of IL-4 producing CD3+ T cells. Both an increase in IL-4 producing type 2 T cells and a reduction of IFN-gamma producing type 1 T cells may contribute to a type 2 skewed memory in response to allergens. Therefore, we suggest exposure to VOCs in association with allergic sensitization to be mediated by a T cell polarization toward the type 2 phenotype" |
| Keywords: | "Air Pollution, Indoor/*adverse effects Cell Polarity/drug effects/*immunology Child, Preschool Cytokines/metabolism *Environmental Exposure Female Humans Hypersensitivity, Immediate/immunology/*physiopathology Immunoglobulin E/*biosynthesis Male Organic C;" |
| Notes: | "MedlineLehmann, I Rehwagen, M Diez, U Seiffart, A Rolle-Kampczyk, U Richter, M Wetzig, H Borte, M Herbarth, O eng Research Support, Non-U.S. Gov't Germany 2002/02/09 Int J Hyg Environ Health. 2001 Dec; 204(4):211-21. doi: 10.1078/1438-4639-00100" |
