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Biosensors (Basel)

Title:		Development and Bioanalytical Applications of a White Light Reflectance Spectroscopy Label-Free Sensing Platform
Author(s):		Koukouvinos G; Petrou P; Goustouridis D; Misiakos K; Kakabakos S; Raptis I;
Address:		"Immunoassay/Immunosensors Lab, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, NCSR 'Demokritos', 15310 Aghia Paraskevi, Greece. geokoukoubinos@yahoo.gr. Immunoassay/Immunosensors Lab, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, NCSR 'Demokritos', 15310 Aghia Paraskevi, Greece. ypetrou@rrp.demokritos.gr. ThetaMetrisis S.A., 12243 Egaleo, Greece. dgousto@teipir.gr. Department of Electronics Engineering TEI of Piraeus, 12244 Egaleo, Greece. dgousto@teipir.gr. Optical sensors Lab, Institute of Nanoscience and Nanotechnology, NCSR 'Demokritos', 15310 Aghia Paraskevi, Greece. k.misiakos@inn.demokritos.gr. Immunoassay/Immunosensors Lab, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, NCSR 'Demokritos', 15310 Aghia Paraskevi, Greece. skakab@rrp.demokritos.gr. ThetaMetrisis S.A., 12243 Egaleo, Greece. i.raptis@inn.demokritos.gr. Optical sensors Lab, Institute of Nanoscience and Nanotechnology, NCSR 'Demokritos', 15310 Aghia Paraskevi, Greece. i.raptis@inn.demokritos.gr"
Journal Title:		Biosensors (Basel)
Year:		2017
Volume:		20171013
Issue:		4
Page Number:		-
DOI:		10.3390/bios7040046
ISSN/ISBN:		2079-6374 (Electronic) 2079-6374 (Linking)
Abstract:		"The development of a sensing platform based on white light reflectance spectroscopy (WLRS) is presented. The evolution of the system, from polymer film characterization and sensing of volatile organic compounds to biosensor for the label-free determination of either high (e.g., proteins) or low molecular weight analytes (e.g., pesticides), is described. At the same time, the passage from single to multi-analyte determinations, and from a laboratory prototype set-up to a compact device appropriate for on-site determination, is outlined. The improvements made on both the sensor and the optical set-up, and the concomitant advances in the analytical characteristics and the robustness of the assays performed with the different layouts, are also presented. Finally, the future perspectives of the system, aiming for the creation of a standalone instrument to be used by non-experts, will be discussed"
Keywords:		*Biosensing Techniques Spectrum Analysis/*methods fast assays label-free determinations low molecular weight molecules protein analytes volatile organic compounds white light reflectance spectroscopy;
Notes:		"MedlineKoukouvinos, Georgios Petrou, Panagiota Goustouridis, Dimitrios Misiakos, Konstantinos Kakabakos, Sotirios Raptis, Ioannis eng Review Switzerland 2017/10/14 Biosensors (Basel). 2017 Oct 13; 7(4):46. doi: 10.3390/bios7040046"