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J Breath Res

Title:		Atmospheric pressure chemical ionization mass spectrometry of pyridine and isoprene: potential breath exposure and disease biomarkers
Author(s):		Kapishon V; Koyanagi GK; Blagojevic V; Bohme DK;
Address:		"Department of Chemistry, Centre for Research in Mass Spectrometry-CRMS, York University, Toronto, Ontario M3J 1P3, Canada"
Journal Title:		J Breath Res
Year:		2013
Volume:		20130412
Issue:		2
Page Number:		26005 -
DOI:		10.1088/1752-7155/7/2/026005
ISSN/ISBN:		1752-7163 (Electronic) 1752-7155 (Linking)
Abstract:		"Volatile organic compounds (VOCs) in exhaled human breath can serve as potential disease-specific and exposure biomarkers and therefore can reveal information about a subject's health and environment. Pyridine, a VOC marker for exposure to tobacco smoke, and isoprene, a liver disease biomarker, were studied using atmospheric pressure chemical ionization mass spectrometry (APCI-MS). While both molecules could be detected in low-ppb levels, interactions of the ionized analytes with their neutral forms and ambient air led to unusual ion/molecule chemistry. The result was a highly dynamic system and a nonlinear response to changes in analyte concentration. Increased presence of ambient water was found to greatly enhance the detection limit of pyridine and only slightly decrease that of isoprene. APCI-MS is shown to be a promising analytical tool in breath analysis with good detection limits, but its application requires a better understanding of the ion/molecule chemistry that may affect VOC quantification from a chemically complex system such as human breath"
Keywords:		Atmospheric Pressure Biomarkers/analysis Breath Tests/*methods Butadienes/*analysis Environmental Illness/*diagnosis/metabolism Exhalation Gases/*chemistry Hemiterpenes/*analysis Humans Mass Spectrometry/*methods Pentanes/*analysis Pyridines/*analysis Vol;
Notes:		"MedlineKapishon, Vitaliy Koyanagi, Gregory K Blagojevic, Voislav Bohme, Diethard K eng Research Support, Non-U.S. Gov't England 2013/04/13 J Breath Res. 2013 Jun; 7(2):026005. doi: 10.1088/1752-7155/7/2/026005. Epub 2013 Apr 12"