| Title: | Biomarker Discovery and Utility in Necrotizing Enterocolitis |
| Author(s): | Goldstein GP; Sylvester KG; |
| Address: | "Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304. Department of Surgery, Division of Pediatric Surgery, 300 Pasteur Drive, Alway Building M116, MC 5733, Stanford, CA 94305. Electronic address: Sylvester@stanford.edu" |
| DOI: | 10.1016/j.clp.2018.10.001 |
| ISSN/ISBN: | 1557-9840 (Electronic) 0095-5108 (Linking) |
| Abstract: | "Necrotizing enterocolitis (NEC) is a devastating disease of prematurity, with no current method for early diagnosis. Diagnosis is particularly challenging, frequently occurring after the disease has progressed to the point of significant and often irreversible intestinal damage. Biomarker research has tremendous potential to advance clinical management of NEC and our understanding of its pathogenesis. This review discusses the need for novel biomarkers in NEC management, evaluates studies investigating such biomarkers, and explains the difficulties associated with translating biomarker discovery into clinical use" |
| Keywords: | "Alpha-Globulins/metabolism Biomarkers/*metabolism Blood Cell Count Breath Tests C-Reactive Protein/metabolism Claudins/metabolism Complement C5a/metabolism Cytokines/metabolism Early Diagnosis Enterocolitis, Necrotizing/diagnosis/*metabolism/microbiology;" |
| Notes: | "MedlineGoldstein, Gregory P Sylvester, Karl G eng UL1 TR001085/TR/NCATS NIH HHS/ Research Support, N.I.H., Extramural Review 2019/02/18 Clin Perinatol. 2019 Mar; 46(1):1-17. doi: 10.1016/j.clp.2018.10.001. Epub 2018 Dec 12" |
