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J Cell Biol


Title:Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction
Author(s):Gallo Castro D; Martin SG;
Address:"Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland. Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland sophie.martin@unil.ch"
Journal Title:J Cell Biol
Year:2018
Volume:20181002
Issue:12
Page Number:4215 - 4229
DOI: 10.1083/jcb.201806016
ISSN/ISBN:1540-8140 (Electronic) 0021-9525 (Print) 0021-9525 (Linking)
Abstract:"The formation of a local zone of Cdc42 GTPase activity, which governs cell polarization in many cell types, requires not only local activation but also switch-off mechanisms. In this study, we identify Rga3, a paralog of Rga4, as a novel Cdc42 GTPase-activating protein (GAP) in the fission yeast Schizosaccharomyces pombe Contrary to Rga4, Rga3 localizes with Cdc42-GTP to sites of polarity. Rga3 is dispensable for cell polarization during mitotic growth, but it limits the lifetime of unstable Cdc42-GTP patches that underlie cell pairing during sexual reproduction, masking a partly compensatory patch-wandering motion. In consequence, cells lacking rga3 hyperpolarize and lose out in mating competition. Rga3 synergizes with the Cdc42 GAPs Rga4 and Rga6 to restrict Cdc42-GTP zone sizes during mitotic growth. Surprisingly, triple-mutant cells, which are almost fully round, retain pheromone-dependent dynamic polarization of Cdc42-GTP, extend a polarized projection, and mate. Thus, the requirement for Cdc42-GTP hydrolysis by GAPs is distinct during polarization by intrinsic or extrinsic cues"
Keywords:GTPase-Activating Proteins/genetics/*metabolism Guanosine Triphosphate/genetics/*metabolism Mitosis/*physiology Schizosaccharomyces/*enzymology/genetics Schizosaccharomyces pombe Proteins/genetics/*metabolism cdc42 GTP-Binding Protein/genetics/*metabolism;
Notes:"MedlineGallo Castro, Daniela Martin, Sophie G eng Research Support, Non-U.S. Gov't 2018/10/04 J Cell Biol. 2018 Dec 3; 217(12):4215-4229. doi: 10.1083/jcb.201806016. Epub 2018 Oct 2"

 
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