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Heredity (Edinb)

Title:		Analogous pleiotropic effects of insecticide resistance genotypes in peach-potato aphids and houseflies
Author(s):		Foster SP; Young S; Williamson MS; Duce I; Denholm I; Devine GJ;
Address:		"Plant and Invertebrate Ecology Division, Rothamsted Research, Harpenden AL5 2JQ, UK"
Journal Title:		Heredity (Edinb)
Year:		2003
Volume:		91
Issue:		2
Page Number:		98 - 106
DOI:		10.1038/sj.hdy.6800285
ISSN/ISBN:		0018-067X (Print) 0018-067X (Linking)
Abstract:		"We show that single-point mutations conferring target-site resistance (kdr) to pyrethroids and DDT in aphids and houseflies, and gene amplification conferring metabolic resistance (carboxylesterase) to organophosphates and carbamates in aphids, can have deleterious pleiotropic effects on fitness. Behavioural studies on peach-potato aphids showed that a reduced response to alarm pheromone was associated with both gene amplification and the kdr target-site mutation. In this species, gene amplification was also associated with a decreased propensity to move from senescing leaves to fresh leaves at low temperature. Housefly genotypes possessing the identical kdr mutation were also shown to exhibit behavioural differences in comparison with susceptible insects. In this species, resistant individuals showed no positional preference along a temperature gradient while susceptible genotypes exhibited a strong preference for warmer temperatures"
Keywords:		Animals Aphids/*genetics DDT/pharmacology Esterases/biosynthesis/genetics Gene Amplification Genotype Houseflies/*genetics Insect Proteins/genetics Insecticide Resistance/*genetics Point Mutation Prunus/parasitology Pyrethrins/pharmacology Sesquiterpenes/;
Notes:		"MedlineFoster, S P Young, S Williamson, M S Duce, I Denholm, I Devine, G J eng Comparative Study Research Support, Non-U.S. Gov't England 2003/07/30 Heredity (Edinb). 2003 Aug; 91(2):98-106. doi: 10.1038/sj.hdy.6800285"