| Title: | Nitric Oxide and Biological Mediators in Pediatric Chronic Rhinosinusitis and Asthma |
| Author(s): | Ferraro VA; Zanconato S; Baraldi E; Carraro S; |
| Address: | "Women's and Children's Health Department, University of Padova, via Giustiniani 2, 35128 Padova, Italy" |
| ISSN/ISBN: | 2077-0383 (Print) 2077-0383 (Electronic) 2077-0383 (Linking) |
| Abstract: | "BACKGROUND: In the context of the so-called unified airway theory, chronic rhinosinusitis (CRS) and asthma may coexist. The inflammation underlying these conditions can be studied through the aid of biomarkers. Main body: We described the main biological mediators that have been studied in pediatric CRS and asthma, and, according to the available literature, we reported their potential role in the diagnosis and management of these conditions. As for CRS, we discussed the studies that investigated nasal nitric oxide (nNO), pendrin, and periostin. As for asthma, we discussed the role of fractional exhaled nitric oxide (feNO), the role of periostin, and that of biological mediators measured in exhaled breath condensate (EBC) and exhaled air (volatile organic compounds, VOCs). CONCLUSION: Among non-invasive biomarkers, nNO seems the most informative in CRS and feNO in asthma. Other biological mediators seem promising, but further studies are needed before they can be applied in clinical practice" |
| Keywords: | biological mediators nitric oxide pediatric asthma pediatric rhinosinusitis; |
| Notes: | "PubMed-not-MEDLINEFerraro, Valentina Agnese Zanconato, Stefania Baraldi, Eugenio Carraro, Silvia eng Review Switzerland 2019/11/17 J Clin Med. 2019 Oct 25; 8(11):1783. doi: 10.3390/jcm8111783" |
