« Previous AbstractInfluence of Non-Saccharomyces Strains on Chemical Characteristics and Sensory Quality of Fruit Spirit    Next AbstractExploring the utility of robots in exposure studies »

Ann Palliat Med

Title:		"Effects of omega-3 supplementation on quality of life, nutritional status, inflammatory parameters, lipid profile, exercise tolerance and inhaled medications in chronic obstructive pulmonary disease"
Author(s):		Fekete M; Szarvas Z; Fazekas-Pongor V; Lehoczki A; Tarantini S; Varga JT;
Address:		"Department of Public Health, Semmelweis University, Faculty of Medicine, Budapest, Hungary. Department of Hematology and Stem Cell Transplantation, South Pest Central Hospital, National Institute for Haematology and Infectious Diseases, Budapest, Hungary. Department of Biochemistry and Molecular Biology at University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, Japan. Department of Pulmonary Rehabilitation, National Koranyi Institute of Pulmonology, Budapest, Hungary; Department of Pulmonology, Semmelweis University, Semmelweis Medical Centre Semmelweis Hospital, Budapest, Hungary"
Journal Title:		Ann Palliat Med
Year:		2022
Volume:		20220802
Issue:		9
Page Number:		2819 - 2829
DOI:		10.21037/apm-22-254
ISSN/ISBN:		2224-5839 (Electronic) 2224-5820 (Linking)
Abstract:		"BACKGROUND: The omega-3 polyunsaturated fatty acids (PUFAs) have an anti-inflammatory effect, beneficial for allergies, asthma, chronic obstructive pulmonary disease (COPD), reduce cholesterol and triglyceride levels and blood inflammatory parameters [C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha)]. The aim of our cross-sectional study was to monitor omega-3 supplementation in patients with severe COPD and assess its association with quality of life, nutritional status, inflammatory parameters, lipid profile, comorbidities, exercise tolerance and inhaled medications. METHODS: Our questionnaire on dietary supplement habits and our validated self-completion questionnaires were filled in by 400 patients with COPD at the National Koranyi Institute of Pulmonology, Hungary, mean age 67 [61-73] years; forced expiratory volume in one second (FEV1) (ref%): 46 [34-58]; 47.5% male, 52.5% female. We used the disease-specific COPD Assessment Test (CAT) questionnaire to measure quality of life. RESULTS: More than half of the study participants (61%) did not consume fish or oilseeds at all. Nineteen patients (4.75%) took omega-3 supplementation regularly, mainly on medical advice (0.5 g/day). We observed significantly lower serum CRP levels [6.0 (1-7.3) vs. 9.7 (7.4-14.4); P=0.044], more favourable lipid profile [triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol] with higher mean body mass index (BMI) [28.1 (22.0-35.3) vs. 24.7 (24.5-30.1); P=0.118], better quality of life CAT: 25 [21-30.5] vs. 26 [20-31]; P=0.519, lower inhaled short-acting bronchodilators use [short-acting beta-agonists (SABAs): 6 (31.58) vs. 209 (54.86); P=0.047], lower number of exacerbations in the previous half year [0 (0-1) vs. 1 (0-2); P=0.023], and higher 6-minute walking distance (6MWD) 300 [177-387] vs. 251 [150-345]; P=0.120 in the group with omega-3 supplementation. CONCLUSIONS: PUFAs are anti-inflammatory and affect the immune system. Our study shows that omega-3 intake of COPD patients is insufficient, and there is an urgent need to develop new anti-inflammatory strategies because only one drug (such as corticosteroids) cannot ease the chronically progressive inflammatory process of COPD"
Keywords:		"Adrenal Cortex Hormones/therapeutic use Bronchodilator Agents/therapeutic use C-Reactive Protein Cholesterol/therapeutic use Cross-Sectional Studies Dietary Supplements Exercise Tolerance *Fatty Acids, Omega-3/therapeutic use Fatty Acids, Unsaturated/ther;"
Notes:		"MedlineFekete, Monika Szarvas, Zsofia Fazekas-Pongor, Vince Lehoczki, Andrea Tarantini, Stefano Varga, Janos Tamas eng China 2022/08/11 Ann Palliat Med. 2022 Sep; 11(9):2819-2829. doi: 10.21037/apm-22-254. Epub 2022 Aug 2"