« Previous Abstract"Effects of academic stress on the levels of oral volatile sulfur compounds, halitosis-related bacteria and stress biomarkers of healthy female undergraduate students"    Next AbstractAnalysis of volatile compounds in some typical Brazilian fruits and juices by SPME-GC method »

Environ Sci Pollut Res Int

Title:		Monitoring human genotoxicity risk associated to urban and industrial Buenos Aires air pollution exposure
Author(s):		de Los AG; Palmieri MA; Giuliani DS; Colman Lerner JE; Maglione G; Andrinolo D; Tasat DR;
Address:		"Center for Environmental Research (CIM) Faculty of Exact Sciences, CONICET, National University of La Plata, Boulevard 120 No. 1489, Buenos Aires, Argentina. Biodiversity and Experimental Biology Department, School of Exact and Natural Sciences, University of Buenos Aires, Av. Int. Guiraldes No. 2160, Buenos Aires, Argentina. Center for Research and Development in Applied Sciences (CINDECA), Faculty of Exact Sciences, CONICET, CIC-PBA, National University of La Plata, 47 y 115 No. 257, Buenos Aires, Argentina. jecolman@quimica.unlp.edu.ar. Department of Histology and Embryology, School of Dentistry, University of Buenos Aires, Marcelo T. de Alvear 2142, Buenos Aires, Argentina. School of Science and Technology, National University of San Martin, 25 de Mayo y Francia, San Martin, Buenos Aires, Argentina"
Journal Title:		Environ Sci Pollut Res Int
Year:		2020
Volume:		20200208
Issue:		12
Page Number:		13995 - 14006
DOI:		10.1007/s11356-020-07863-9
ISSN/ISBN:		1614-7499 (Electronic) 0944-1344 (Linking)
Abstract:		"The quality of life in large megacities is directly affected by its air quality. In urban environments, suspended particles from anthropogenic origin is one of the main air contaminants identified as highly genotoxic, mutagenic, or carcinogenic. Atmospheric monitoring is therefore imperative, and bioassays to detect the effects of genotoxic agents give usually excellent results. Analysis of micronucleus (MN) in exfoliated oral mucosa cells is a sensitive non-invasive method for monitoring genetic damage in human populations. The first aim of this study was to analyze and characterize levels of volatile organic compounds (VOCs), particulate matter (PM), and polycyclic aromatic hydrocarbons (PAHs) in two areas from Buenos Aires: La Plata city, an urban (U) area and Ensenada, an industrial (I) area. Secondly, we evaluated the possible health risk of its inhabitants through a simple genotoxic assay on exfoliated oral mucosa cells. Whole blood cell count and nuclear abnormalities frequencies were evaluated in the exfoliated oral mucosa cells from urban and industrial inhabitants. Smoking habit represented a significant factor increasing MN percentage while, age did not increase the production of any of the nuclear aberrations assayed (micronuclei, binucleated, karyorrhexis) when the inhabitants from the urban and the industrial areas were compared. In addition, changes in MN and binucleated cell percentages in males and females were found to be area-dependent. We suggest that regardless PM concentration, PM-specific characteristics (size, shape, chemical elements, etc.) and VOCs levels could be responsible for the different harmful genotoxic effects seen in the two areas. Although this is a preliminary study, our results allowed to recognize that individuals living in both the urban and the industrial areas could be considered susceptible groups and should periodically undergo biological monitoring and appropriate care"
Keywords:		Air Pollutants/*analysis Air Pollution/*analysis Cities DNA Damage Environmental Monitoring Female Humans Male Particulate Matter/analysis Polycyclic Aromatic Hydrocarbons/*analysis Quality of Life Air pollution Genotoxicity Industrial environment Micronu;
Notes:		"Medlinede Los A Gutierrez, Maria Palmieri, Monica A Giuliani, Daniela S Colman Lerner, Jorge E Maglione, Guillermo Andrinolo, Dario Tasat, Deborah R eng Germany 2020/02/09 Environ Sci Pollut Res Int. 2020 Apr; 27(12):13995-14006. doi: 10.1007/s11356-020-07863-9. Epub 2020 Feb 8"