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J Infect Dis

Title:		"Incidence of hemolysin, gelatinase, and aggregation substance among enterococci isolated from patients with endocarditis and other infections and from feces of hospitalized and community-based persons"
Author(s):		Coque TM; Patterson JE; Steckelberg JM; Murray BE;
Address:		"Department of Internal Medicine, University of Texas Medical School, Houston 77030, USA"
Journal Title:		J Infect Dis
Year:		1995
Volume:		171
Issue:		5
Page Number:		1223 - 1229
DOI:		10.1093/infdis/171.5.1223
ISSN/ISBN:		0022-1899 (Print) 0022-1899 (Linking)
Abstract:		"The presence of hemolysin, gelatinase, and aggregation substance (by use of a probe known to hybridize to most pheromone-responsive plasmids) was determined in 192 isolates of Enterococcus faecalis from patients with endocarditis or other infections and fecal isolates from hospitalized patients or healthy volunteers, and in 86 non-E. faecalis isolates. Hemolysin was more common in nonendocarditis clinical isolates and in hospital fecal isolates (37% and 31%, respectively) than among endocarditis and community fecal isolates (16% and 20%, respectively). Gelatinase and aggregation substance, respectively, were found in 54% and 52% of isolates from endocarditis, in 58% and 72% of isolates from other infections, in 62% and 56% of hospital fecal isolates, and in 27% and 30% of fecal isolates from healthy volunteers. All 86 non-E. faecalis enterococcal isolates were negative for these traits. The absence of hemolysin, gelatinase, or the aggregation substance gene in > 45% of endocarditis E. faecalis isolates suggests that while these traits may play a role in virulence, other properties are also important"
Keywords:		"Bacterial Proteins/*analysis/genetics Base Sequence Biomarkers DNA, Bacterial/analysis Drug Resistance, Microbial Endocarditis, Bacterial/*microbiology Enterococcus faecalis/drug effects/enzymology/isolation & purification/*pathogenicity Feces/microbiolog;"
Notes:		"MedlineCoque, T M Patterson, J E Steckelberg, J M Murray, B E eng Research Support, Non-U.S. Gov't 1995/05/01 J Infect Dis. 1995 May; 171(5):1223-9. doi: 10.1093/infdis/171.5.1223"