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Mol Cell Biol

Title:		Quantitation of alpha-factor internalization and response during the Saccharomyces cerevisiae cell cycle
Author(s):		Zanolari B; Riezman H;
Address:		"Biocenter, University of Basel, Switzerland"
Journal Title:		Mol Cell Biol
Year:		1991
Volume:		11
Issue:		10
Page Number:		5251 - 5258
DOI:		10.1128/mcb.11.10.5251-5258.1991
ISSN/ISBN:		0270-7306 (Print) 1098-5549 (Electronic) 0270-7306 (Linking)
Abstract:		"The alpha-factor pheromone binds to specific cell surface receptors on Saccharomyces cerevisiae a cells. The pheromone is then internalized, and cell surface receptors are down-regulated. At the same time, a signal is transmitted that causes changes in gene expression and cell cycle arrest. We show that the ability of cells to internalize alpha-factor is constant throughout the cell cycle, a cells are also able to respond to pheromone throughout the cycle even though there is cell cycle modulation of the expression of two pheromone-inducible genes, FUS1 and STE2. Both of these genes are expressed less efficiently near or just after the START point of the cell cycle in response to alpha-factor. For STE2, the basal level of expression is modulated in the same manner"
Keywords:		"Cell Cycle Endocytosis *Gene Expression Regulation, Fungal Genes, Fungal/genetics Kinetics Mating Factor Microscopy, Fluorescence Peptides/*metabolism/pharmacology Receptors, Cell Surface/genetics/metabolism Receptors, Mating Factor *Receptors, Peptide Sa;"
Notes:		"MedlineZanolari, B Riezman, H eng Research Support, Non-U.S. Gov't 1991/10/01 Mol Cell Biol. 1991 Oct; 11(10):5251-8. doi: 10.1128/mcb.11.10.5251-5258.1991"