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J Clin Periodontol

Title:		A study of triclosan and its solubilizers as inhibitors of oral malodour
Author(s):		Young A; Jonski G; Rolla G;
Address:		"Department of Cariology, Faculty of Dentistry, University of Oslo, Oslo, Norway. alixr@odont.uio.no"
Journal Title:		J Clin Periodontol
Year:		2002
Volume:		29
Issue:		12
Page Number:		1078 - 1081
DOI:		10.1034/j.1600-051x.2002.291205.x
ISSN/ISBN:		0303-6979 (Print) 0303-6979 (Linking)
Abstract:		"BACKGROUND: It is known that the detergents or organic solvents used to solubilize lipid-soluble triclosan can affect the biological activities exhibited by this molecule, such as its antibacterial, antiplaque, and anti-inflammatory effects. OBJECTIVE: To examine whether solubilizing agents influence the effect of triclosan against formation of volatile sulphur compounds (VSC), as these are known to be a major component of oral malodour. MATERIAL AND METHODS: Part A: one ml of human whole saliva (n = 10) was incubated for 24 h at 37 degrees C in a closed test tube with addition of 10 micro l triclosan solubilized in alcohol. Part B: in a clinical experiment, VSC formation enhanced by mouth-rinses with cysteine was followed by subjects (n = 9) rinsing with triclosan solubilized in different detergents and organic solvents. The amount and nature of VSC in the saliva headspace and in the mouth air of the test subjects were determined by gas chromatography. RESULTS: Triclosan had a marked dose-dependent effect against VSC in vitro when solubilized in alcohol, independent of the alcohol per se. In vivo, triclosan lost its anti-VSC effect when solubilized in oil, in an uncharged detergent or in a chromophor, whereas it maintained its effect when solubilized in a combination of sodium lauryl sulphate, propylene glycol and water. CONCLUSION: The solubilizing agent influences the anti-VSC effect of triclosan"
Keywords:		"Adult Aged Analysis of Variance Anti-Infective Agents, Local/*chemistry/*therapeutic use Breath Tests Chromatography, Gas Dose-Response Relationship, Drug Halitosis/metabolism/*prevention & control Humans Middle Aged Mouthwashes/*chemistry/*therapeutic us;"
Notes:		"MedlineYoung, Alix Jonski, Grazyna Rolla, Gunnar eng Clinical Trial Controlled Clinical Trial 2002/12/21 J Clin Periodontol. 2002 Dec; 29(12):1078-81. doi: 10.1034/j.1600-051x.2002.291205.x"