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Mol Biol Cell

Title:		"The same receptor, G protein, and mitogen-activated protein kinase pathway activate different downstream regulators in the alternative white and opaque pheromone responses of Candida albicans"
Author(s):		Yi S; Sahni N; Daniels KJ; Pujol C; Srikantha T; Soll DR;
Address:		"Department of Biology, The University of Iowa, Iowa City, IA 52242, USA"
Journal Title:		Mol Biol Cell
Year:		2008
Volume:		20071227
Issue:		3
Page Number:		957 - 970
DOI:		10.1091/mbc.e07-07-0688
ISSN/ISBN:		1939-4586 (Electronic) 1059-1524 (Print) 1059-1524 (Linking)
Abstract:		"Candida albicans must undergo a switch from white to opaque to mate. Opaque cells then release mating type-specific pheromones that induce mating responses in opaque cells. Uniquely in C. albicans, the same pheromones induce mating-incompetent white cells to become cohesive, form an adhesive basal layer of cells on a surface, and then generate a thicker biofilm that, in vitro, facilitates mating between minority opaque cells. Through mutant analysis, it is demonstrated that the pathways regulating the white and opaque cell responses to the same pheromone share the same upstream components, including receptors, heterotrimeric G protein, and mitogen-activated protein kinase cascade, but they use different downstream transcription factors that regulate the expression of genes specific to the alternative responses. This configuration, although common in higher, multicellular systems, is not common in fungi, and it has not been reported in Saccharomyces cerevisiae. The implications in the evolution of multicellularity in higher eukaryotes are discussed"
Keywords:		"Biofilms/drug effects Biomarkers/metabolism Candida albicans/*cytology/*enzymology/genetics/physiology Fungal Proteins/genetics/metabolism GTP-Binding Proteins/*metabolism Gene Expression Regulation, Fungal/drug effects Genes, Switch Mitogen-Activated Pro;"
Notes:		"MedlineYi, Song Sahni, Nidhi Daniels, Karla J Pujol, Claude Srikantha, Thyagarajan Soll, David R eng AI-2392/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2007/12/29 Mol Biol Cell. 2008 Mar; 19(3):957-70. doi: 10.1091/mbc.e07-07-0688. Epub 2007 Dec 27"