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Lung

Title:		Volatile Organic Compounds in Exhaled Breath of Idiopathic Pulmonary Fibrosis for Discrimination from Healthy Subjects
Author(s):		Yamada YI; Yamada G; Otsuka M; Nishikiori H; Ikeda K; Umeda Y; Ohnishi H; Kuronuma K; Chiba H; Baumbach JI; Takahashi H;
Address:		"Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, South-1 West-16, Chuo-ku, Sapporo, 060-8543, Japan. Department of Respiratory Medicine, Hakodate Goryoukaku Hospital, 38-3 Goryoukaku-cho, Hakodate, Hokkaido, 040-8611, Japan. Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, South-1 West-16, Chuo-ku, Sapporo, 060-8543, Japan. gyamada@sapmed.ac.jp. Department of Public Health, Sapporo Medical University School of Medicine, South-1 West-16, Chuo-ku, Sapporo, 060-8543, Japan. Department of Chemistry & Center for Research and Education 'Process Analysis & Technology', Reutlingen University, Alteburgstrasse 150, 72762, Reutlingen, Germany"
Journal Title:		Lung
Year:		2017
Volume:		20170301
Issue:		2
Page Number:		247 - 254
DOI:		10.1007/s00408-017-9979-3
ISSN/ISBN:		1432-1750 (Electronic) 0341-2040 (Linking)
Abstract:		"Purpose Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from healthy subjects. Methods VOCs in the exhaled breath of 40 IPF patients and 55 healthy controls were measured using a multi-capillary column and ion mobility spectrometer. The patients were examined by pulmonary function tests, blood gas analysis, and serum biomarkers of interstitial pneumonia. Results We detected 85 VOC peaks in the exhaled breath of IPF patients and controls. IPF patients showed 5 significant VOC peaks; p-cymene, acetoin, isoprene, ethylbenzene, and an unknown compound. The VOC peak of p-cymene was significantly lower (p < 0.001), while the VOC peaks of acetoin, isoprene, ethylbenzene, and the unknown compound were significantly higher (p < 0.001 for all) compared with the peaks of controls. Comparing VOC peaks with clinical parameters, negative correlations with VC (r =-0.393, p = 0.013), %VC (r =-0.569, p < 0.001), FVC (r = -0.440, p = 0.004), %FVC (r =-0.539, p < 0.001), DLco (r =-0.394, p = 0.018), and %DLco (r =-0.413, p = 0.008) and a positive correlation with KL-6 (r = 0.432, p = 0.005) were found for p-cymene. Conclusion We found characteristic 5 VOCs in the exhaled breath of IPF patients. Among them, the VOC peaks of p-cymene were related to the clinical parameters of IPF. These VOCs may be useful biomarkers of IPF"
Keywords:		"Acetoin/analysis Adult Aged Aged, 80 and over Benzene Derivatives/analysis Breath Tests Butadienes/analysis Case-Control Studies Cymenes Female Healthy Volunteers Hemiterpenes/analysis Humans Idiopathic Pulmonary Fibrosis/*diagnosis/*physiopathology Male;"
Notes:		"MedlineYamada, Yu-Ichi Yamada, Gen Otsuka, Mitsuo Nishikiori, Hirotaka Ikeda, Kimiyuki Umeda, Yasuaki Ohnishi, Hirofumi Kuronuma, Koji Chiba, Hirofumi Baumbach, Jorg Ingo Takahashi, Hiroki eng 2017/03/02 Lung. 2017 Apr; 195(2):247-254. doi: 10.1007/s00408-017-9979-3. Epub 2017 Mar 1"