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J Anal Toxicol

Title:		"A simple, reliable method for the determination of chlorinated volatile organics in human breath and air using glass sampling tubes"
Author(s):		Stein VB; Narang RS; Wilson L; Aldous KM;
Address:		"New York State Department of Health, Wadsworth Center, Albany 12201-0509, USA"
Journal Title:		J Anal Toxicol
Year:		1996
Volume:		20
Issue:		3
Page Number:		145 - 150
DOI:		10.1093/jat/20.3.145
ISSN/ISBN:		0146-4760 (Print) 0146-4760 (Linking)
Abstract:		"A method for determining chloroform, 1,1,1-trichloroethane, carbon tetrachloride, and trichloroethene in breath samples was developed. It consisted of collecting samples in 40-ml. glass-silanized tubes that were 16-in. long and had a 0.64-in. diameter. The ends tapered, resulting in a tube with a 1/4-in. diameter that was 1 3/4-in. long; each end had a shutoff valve attached. One end had a strip of rubber tube attached to the shutoff valve for collecting the breath sample, and the other end contained a 1/4-in. Swagelok nut with a rubber septum for withdrawing the sample. Samples were withdrawn using a pressure-lock, gastight syringe, and they were injected onto a gas chromatograph fitted with an electron-capture detector. The analytes were stable for at least 22 days in these tubes. The method detection limit was determined to be 0.03, 0.08, 0.04, and 0.04 pg/ml. for chloroform, 1,1,1-trichloroethane, carbon tetrachloride, and trichloroethene, respectively. Precision, based on 13 injections, was determined to be 13% for 0.09 pg chloroform, 13% for 0.21 pg 1,1,1-trichloroethane, 8% for 0.16 pg carbon tetrachloride, and 14% for 0.1 pg trichloroethene. In all, the proposed method is a sensitive and reliable one for determining volatile organic compounds in breath and a method that can also be applied to air sampling"
Keywords:		"Air Pollutants/*analysis Air Pollution, Indoor *Breath Tests Carbon Tetrachloride/*analysis/metabolism Chloroform/*analysis/metabolism Chromatography, Gas Glass Humans Reference Standards Reproducibility of Results Solvents/*analysis/metabolism Specimen H;"
Notes:		"MedlineStein, V B Narang, R S Wilson, L Aldous, K M eng England 1996/05/01 J Anal Toxicol. 1996 May-Jun; 20(3):145-50. doi: 10.1093/jat/20.3.145"