| Title: | TD-GC-MS Investigation of the VOCs Released from Blood Plasma of Dogs with Cancer |
| Author(s): | Selyanchyn R; Nozoe T; Matsui H; Kadosawa T; Lee SW; |
| Address: | "Graduate School of Environmental Engineering, the University of Kitakyushu, 1-1 Hibikino, Wakamatsu-ku, Kitakyushu 808-0135, Japan. romanselyanchyn@gmail.com. Graduate School of Environmental Engineering, the University of Kitakyushu, 1-1 Hibikino, Wakamatsu-ku, Kitakyushu 808-0135, Japan. s1maa007@eng.kitakyu-u.ac.jp. Shinkou Seiki Co. Ltd., 1-18-3, Maidashi, Higashi-ku, Fukuoka 812-8581, Japan. matsui@shinkouseiki.co.jp. Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, 582, Midorimachi, Bunkyodai, Ebetsu 069-8501, Japan. kado@rakuno.ac.jp. Graduate School of Environmental Engineering, the University of Kitakyushu, 1-1 Hibikino, Wakamatsu-ku, Kitakyushu 808-0135, Japan. leesw@kitakyu-u.ac.jp" |
| DOI: | 10.3390/diagnostics3010068 |
| ISSN/ISBN: | 2075-4418 (Print) 2075-4418 (Electronic) 2075-4418 (Linking) |
| Abstract: | "An analytical TD-GC-MS method was developed and used for the assessment of volatile organic compounds (VOCs) released from the blood plasma of dogs with/without cancer. VOCs released from 40 samples of diseased blood and 10 control samples were compared in order to examine the difference between both sample groups that were showing qualitatively similar results independent from the disease's presence. However, mild disturbances in the spectra of dogs with cancer in comparison with the control group were observed, and six peaks (tentatively identified by comparison with mass spectral library as hexanal, octanal, toluene, 2-butanone, 1-octen-3-ol and pyrrole) revealed statistically significant differences between both sample groups, thereby suggesting that these compounds are potential biomarkers that can be used for cancer diagnosis based on the blood plasma TD-GC-MS analysis. Statistical comparison with the application of principal component analysis (PCA) provided accurate discrimination between the cancer and control groups, thus demonstrating stronger biochemical perturbations in blood plasma when cancer is present" |
| Keywords: | Td-gc-ms cancer markers dog blood plasma volatile organic compounds; |
| Notes: | "PubMed-not-MEDLINESelyanchyn, Roman Nozoe, Takuma Matsui, Hidetaka Kadosawa, Tsuyoshi Lee, Seung-Woo eng Switzerland 2013/01/01 Diagnostics (Basel). 2013 Jan 16; 3(1):68-83. doi: 10.3390/diagnostics3010068" |
