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Cell

Title:		"RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor"
Author(s):		Powers S; Michaelis S; Broek D; Santa Anna S; Field J; Herskowitz I; Wigler M;
Address:
Journal Title:		Cell
Year:		1986
Volume:		47
Issue:		3
Page Number:		413 - 422
DOI:		10.1016/0092-8674(86)90598-2
ISSN/ISBN:		0092-8674 (Print) 0092-8674 (Linking)
Abstract:		"We have identified a gene (SUPH) of S. cerevisiae that is required for both RAS function and mating by cells of a mating type. supH is allelic to ste16, a gene required for the production of the mating pheromone a-factor. Both RAS and a-factor coding sequences terminate with the potential acyltransferase recognition sequence Cys-A-A-X, where A is an aliphatic amino acid. Mutations in SUPH-STE16 prevent the membrane localization and maturation of RAS protein, as well as the fatty acid acylation of it and other membrane proteins. We propose the designation RAM (RAS protein and a-factor maturation function) for SUPH and STE16. RAM may encode an enzyme responsible for the modification and membrane localization of proteins with this C-terminal sequence"
Keywords:		"Acylation Adenylyl Cyclases/metabolism Alleles Fungal Proteins/*genetics *Genes, Fungal *Genes, Mating Type, Fungal Mating Factor Membrane Proteins/analysis/genetics *Peptide Biosynthesis Peptides/genetics Saccharomyces cerevisiae/*genetics *ras Proteins;"
Notes:		"MedlinePowers, S Michaelis, S Broek, D Santa Anna, S Field, J Herskowitz, I Wigler, M eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1986/11/07 Cell. 1986 Nov 7; 47(3):413-22. doi: 10.1016/0092-8674(86)90598-2"