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J Comp Physiol A Neuroethol Sens Neural Behav Physiol

Title:		The protein pheromone temptin is an attractant of the gastropod Biomphalaria glabrata
Author(s):		Pila EA; Peck SJ; Hanington PC;
Address:		"School of Public Health, University of Alberta, 357F South Academic Building, Edmonton, AB, T6G2G7, Canada. School of Public Health, University of Alberta, 357F South Academic Building, Edmonton, AB, T6G2G7, Canada. pch1@ualberta.ca"
Journal Title:		J Comp Physiol A Neuroethol Sens Neural Behav Physiol
Year:		2017
Volume:		20170706
Issue:		10
Page Number:		855 - 866
DOI:		10.1007/s00359-017-1198-0
ISSN/ISBN:		1432-1351 (Electronic) 0340-7594 (Linking)
Abstract:		"The freshwater snail Biomphalaria glabrata has drawn much research interest by virtue of it being one of the intermediate hosts of the parasitic flatworm Schistosoma mansoni, a causative agent of human schistosomiasis. Schistosomiasis is a chronic disease that affects over 260 million people globally, particularly in tropical and sub-tropical regions. One strategy that has been proposed as a way to prevent human infection by the parasite, involves the use of pheromone traps to lure the snail host away from areas of human activity. This requires an understanding of chemosensory communication in B. glabrata, especially of the chemoattractive factors. Although evidence indicates that specific chemical communication takes place, little is known about chemoattractants produced by the snail itself. Here, we report on the functional characterization of an endogenously produced temptin-like protein (BgTemptin) from B. glabrata and demonstrate that recombinant BgTemptin is attractive to this snail. Exposure of B. glabrata to BgTemptin results in 81% (lane maze) and 70% (T-maze) time spent near to the BgTemptin source. This effect, which is dependent on the concentration of the protein, provides another tool that can be further developed and used in efforts to control and eliminate schistosomiasis"
Keywords:		"Animals Behavior, Animal/*drug effects Biomphalaria/chemistry/*drug effects/*metabolism Dose-Response Relationship, Drug Maze Learning/drug effects Pheromones/genetics/metabolism/*pharmacology Phylogeny Biomphalaria glabrata Gastropod Pheromone Schistosom;"
Notes:		"MedlinePila, Emmanuel A Peck, Shauna J Hanington, Patrick C eng 418540/Natural Sciences and Engineering Research Council of Canada/ Germany 2017/07/08 J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 Oct; 203(10):855-866. doi: 10.1007/s00359-017-1198-0. Epub 2017 Jul 6"