| Title: | Environmentally friendly ionic liquid-in-water microemulsions for extraction of hydrophilic and lipophilic components from Flos Chrysanthemi |
| Author(s): | Chen J; Cao J; Gao W; Qi LW; Li P; |
| Address: | "State Key Laboratory of Natural Medicines and Department of Pharmacognosy, China Pharmaceutical University, No. 24 Tongjia Lane, Nanjing 210009, China. liping2004@126.com Lianwenqi2004@126.com" |
| ISSN/ISBN: | 1364-5528 (Electronic) 0003-2654 (Linking) |
| Abstract: | "Ionic liquids (ILs) have numerous chemical applications as environmentally green solvents that are extending into microemulsion applications. In this work, a novel benign IL-in-water microemulsion system modified by an IL surfactant has been proposed for simultaneous extraction of hydrophilic and lipophilic constituents from Flos Chrysanthemi (Chrysanthemum morifolium). Constituents were analyzed by rapid-resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A mixture-design approach was used to optimize the IL surfactant and the IL oil phase in the microemulsion system. Microemulsions consisting of 6.0% 1-dodecyl-3-methylimidazolium hydrogen sulfate, 0.1% 1-vinyl-3-methylimidazolium hexafluorophosphate and 93.9% water offered the acceptable extract efficiency that are comparable to or even better than conventional volatile organic solvents. This assay was fully validated with respect to the linearity of response (r(2) > 0.999 over two orders of magnitude), precision (intra-RSD < 0.49 and inter-day RSD < 2.21), and accuracy (recoveries ranging from 93.73% to 101.84%). The proposed IL-in-water microemulsion method provided an environmentally friendly alternative for efficient extraction of compounds from Flos Chrysanthemi and could be extended to complex environmental and pharmaceutical samples" |
| Keywords: | *Chrysanthemum Emulsions Green Chemistry Technology/*methods Hydrophobic and Hydrophilic Interactions Ionic Liquids/*chemistry Liquid Phase Microextraction/*methods Plant Extracts/*analysis/chemistry Water/*chemistry; |
| Notes: | "MedlineChen, Jue Cao, Jun Gao, Wen Qi, Lian-Wen Li, Ping eng Research Support, Non-U.S. Gov't England 2013/08/10 Analyst. 2013 Oct 21; 138(20):5933-41. doi: 10.1039/c3an00957b. Epub 2013 Aug 9" |
