| Title: | Positive identification of the puberty-accelerating pheromone of the house mouse: the volatile ligands associating with the major urinary protein |
| Author(s): | Novotny MV; Ma W; Wiesler D; Zidek L; |
| Address: | "Department of Chemistry, Indiana University, Bloomington 47405, USA. novotny@indiana.edu" |
| ISSN/ISBN: | 0962-8452 (Print) 1471-2954 (Electronic) 0962-8452 (Linking) |
| Abstract: | "Five structurally diverse small ligands, all binding to the major urinary protein (MUP) of the male house mouse, show individually puberty-accelerating pheromonal activity in the recipient females. A recombinant MUP (identical structurally to the natural protein) has shown no biological activity. While four of these ligands were previously implicated in oestrus synchronization (Whitten effect), the same chemosignals now appear responsible for both sexual maturation and cycling in adult females" |
| Keywords: | "Animals Bridged Bicyclo Compounds, Heterocyclic/chemistry/*metabolism Female Ketones/chemistry/*metabolism Ligands Male Mice Mice, Inbred ICR Molecular Structure Pheromones/*metabolism Proteins/*metabolism Recombinant Fusion Proteins/metabolism Sesquiterp;" |
| Notes: | "MedlineNovotny, M V Ma, W Wiesler, D Zidek, L eng DC 02418/DC/NIDCD NIH HHS/ Research Support, U.S. Gov't, P.H.S. England 1999/12/10 Proc Biol Sci. 1999 Oct 7; 266(1432):2017-22. doi: 10.1098/rspb.1999.0880" |
