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Lab Chip

Title:		A multidimensional micro gas chromatograph employing a parallel separation multi-column chip and stop-flow muGC x muGCs configuration
Author(s):		Chen BX; Hung TY; Jian RS; Lu CJ;
Address:		"Chemistry Department, National Taiwan Normal University, Ting-Chow Rd., Taipei, Taiwan"
Journal Title:		Lab Chip
Year:		2013
Volume:		13
Issue:		7
Page Number:		1333 - 1341
DOI:		10.1039/c2lc41179b
ISSN/ISBN:		1473-0189 (Electronic) 1473-0189 (Linking)
Abstract:		"A dual-chip, multidimensional micro gas chromatographic module was designed, built and evaluated. Column chips were fabricated on a silicon wafer with an etched rectangular channel 100 mum (width) x 250 mum (depth) using a deep reactive ion etching (DRIE) process. The column chip for the first GC dimension was 3 m long and was coated with polydimethylsiloxane (DB-1) as the stationary phase. The columns on the second dimensional chip were etched with the same width and depth as the first chip, but the flow channel was split into three parallel columns, 1 m long, on the same sized silicon chip (i.e., 3 cm x 3 cm). These three parallel columns on the second chip were coated with polyethylene oxide (DB-Wax), trifluoropropylpolymethylsilicone (OV-210) and cyanopropylmethylphenylmethylpolysilicone (OV-225), accordingly, in order to provide diversified chromatographic retention. These two chips were connected via a stop-flow configuration to simultaneously generate multiple two-dimensional gas chromatograms for every analysis. This stop-flow muGC x muGCs design allowed the first column to function as a pre-separator and as a sequencing injector for the second parallel-separation chip. Fifteen volatile organic compounds with boiling points that ranged from 80-131 degrees C with various functional groups were tested using this muGC x muGCs module. Three discrete 2-D chromatograms were generated simultaneously, which demonstrated the advantages of simultaneously combining GC x GC with parallel separation GCs in microchip chromatography. The total traveling length in the column was only 4 m for each eluted peak and fully resolved separation was achieved through the cross reference among triplet 2-D chromatograms"
Keywords:
Notes:		"PubMed-not-MEDLINEChen, Bo-Xun Hung, Te-Yu Jian, Rih-Sheng Lu, Chia-Jung eng England 2013/02/06 Lab Chip. 2013 Apr 7; 13(7):1333-41. doi: 10.1039/c2lc41179b"